Detailed information of TA system TA234933

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 320160..320344
• Replicon: chromosome
• Accession: NZ_CP091876
• Organism: Staphylococcus aureus strain FRI-1169

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: MAK06_RS01535
• Protein ID: WP_000482650.1
• Coordinates: 320160..320267 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	320284..320344 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK06_RS01510	315522..315995	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
MAK06_RS01515	316118..317329	-	1212	WP_238097439.1	multidrug effflux MFS transporter	-
MAK06_RS01520	317511..318170	-	660	WP_000831298.1	membrane protein	-
MAK06_RS01525	318230..319372	-	1143	WP_001176863.1	glycerate kinase	-
MAK06_RS01530	319640..320026	+	387	WP_000779358.1	flippase GtxA	-
MAK06_RS01535	320160..320267	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	320284..320344	-	61	-	-	Antitoxin
MAK06_RS01540	320895..322658	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
MAK06_RS01545	322683..324416	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MAK06_RS01550	324647..324814	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T234933 WP_000482650.1 NZ_CP091876:320160-320267 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T234933 NZ_LR134151:c3883608-3883339 [Serratia plymuthica]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
TGCGCTCATTTTACAGCGCGGGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCTCTTTATGTACCGGTTGGGTAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTAGT
GTTATTCACGCTAAACGAGAATATCCCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT234933 NZ_CP091876:c320344-320284 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin