Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 288321..288844 Replicon chromosome
Accession NZ_CP091876
Organism Staphylococcus aureus strain FRI-1169

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MAK06_RS01395 Protein ID WP_000074048.1
Coordinates 288578..288844 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MAK06_RS01390 Protein ID WP_000587616.1
Coordinates 288321..288578 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK06_RS01370 (283401) 283401..284594 + 1194 WP_000675401.1 MFS transporter -
MAK06_RS01375 (284818) 284818..285567 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
MAK06_RS01380 (285762) 285762..287339 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
MAK06_RS01385 (287507) 287507..287962 - 456 WP_000732082.1 DUF1307 domain-containing protein -
MAK06_RS01390 (288321) 288321..288578 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MAK06_RS01395 (288578) 288578..288844 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MAK06_RS01400 (289199) 289199..290275 + 1077 WP_001076671.1 M42 family metallopeptidase -
MAK06_RS01405 (290523) 290523..291185 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
MAK06_RS01410 (291178) 291178..291954 + 777 WP_000072146.1 iron export ABC transporter permease subunit FetB -
MAK06_RS01415 (292350) 292350..293537 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T234932 WP_000074048.1 NZ_CP091876:288578-288844 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T234932 NZ_LR134151:c3144239-3143823 [Serratia plymuthica]
GTGAACAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCTGTGATCAAACGCCT
GGAGCAGGCGGTGCTGCGTAACCACCGCATCGTGGTCTCCGCCATCACCTACGCGGAAATGCGTTTCGGCGCGATCGGGA
AGAAGGCCTCGCCGCGCCATGCGCAACTGGTCGACGCGTTCTGCACCCGCCTCGATGCCGTGCTGGCCTGGGACCGGGCG
GCGGTGGACGCCACCACGGAAATCAAGGCTGCCCTGGCCGCGGCCGGGACGCCGATCGGCCCGAACGATACGGCGATCGC
CGGGCACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTACCGGGCCTGAAGCAGG
AGGACTGGGTGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT234932 WP_000587616.1 NZ_CP091876:288321-288578 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT234932 NZ_LR134151:c3144466-3144236 [Serratia plymuthica]
ATGCGCACAGTTTCTATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCCTTTGCTCAGTTTG
AAAAAGCCGACGCAGATTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References