Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2626433..2626950 Replicon chromosome
Accession NZ_CP091875
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MAK07_RS13260 Protein ID WP_000251928.1
Coordinates 2626433..2626699 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MAK07_RS13265 Protein ID WP_000584497.1
Coordinates 2626699..2626950 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK07_RS13235 (2621641) 2621641..2622177 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MAK07_RS13240 (2622645) 2622645..2623469 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MAK07_RS13245 (2623672) 2623672..2623854 - 183 WP_000079140.1 hypothetical protein -
MAK07_RS13250 (2623940) 2623940..2624407 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MAK07_RS13255 (2624593) 2624593..2626140 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MAK07_RS13260 (2626433) 2626433..2626699 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MAK07_RS13265 (2626699) 2626699..2626950 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MAK07_RS13270 (2627114) 2627114..2627214 - 101 Protein_2576 hypothetical protein -
MAK07_RS13275 (2627221) 2627221..2627820 - 600 WP_000162804.1 DsbA family protein -
MAK07_RS13280 (2627839) 2627839..2628201 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MAK07_RS13285 (2628456) 2628456..2629706 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MAK07_RS13290 (2629803) 2629803..2630534 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MAK07_RS13295 (2630531) 2630531..2631250 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T234929 WP_000251928.1 NZ_CP091875:c2626699-2626433 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T234929 NZ_LR134151:2047528-2047624 [Serratia plymuthica]
AACAAGCCCTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT234929 WP_000584497.1 NZ_CP091875:c2626950-2626699 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT234929 NZ_LR134151:c2047628-2047484 [Serratia plymuthica]
AGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTTTGTGCAGGGCTTGTTCAGCCATGCACTTTAAGAGTAGCTTACCGCGCTAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References