Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2196153..2196576 Replicon chromosome
Accession NZ_CP091875
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag MAK07_RS10940 Protein ID WP_001065091.1
Coordinates 2196325..2196576 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag MAK07_RS10935 Protein ID WP_000028422.1
Coordinates 2196153..2196335 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK07_RS10890 (2191538) 2191538..2193199 - 1662 WP_000625087.1 terminase large subunit -
MAK07_RS10895 (2193196) 2193196..2193540 - 345 WP_000402904.1 hypothetical protein -
MAK07_RS10900 (2193671) 2193671..2193970 - 300 WP_000988330.1 HNH endonuclease -
MAK07_RS10905 (2194202) 2194202..2194618 - 417 WP_000590122.1 hypothetical protein -
MAK07_RS10910 (2194646) 2194646..2194846 - 201 WP_000265043.1 DUF1514 family protein -
MAK07_RS10915 (2194846) 2194846..2194995 - 150 WP_000595265.1 transcriptional activator RinB -
MAK07_RS10920 (2194992) 2194992..2195378 - 387 WP_000592207.1 hypothetical protein -
MAK07_RS10925 (2195375) 2195375..2195581 - 207 WP_000195803.1 DUF1381 domain-containing protein -
MAK07_RS10930 (2195618) 2195618..2196160 - 543 WP_000185659.1 dUTP pyrophosphatase -
MAK07_RS10935 (2196153) 2196153..2196335 - 183 WP_000028422.1 hypothetical protein Antitoxin
MAK07_RS10940 (2196325) 2196325..2196576 - 252 WP_001065091.1 DUF1024 family protein Toxin
MAK07_RS10945 (2196569) 2196569..2196736 - 168 WP_001624242.1 hypothetical protein -
MAK07_RS10950 (2196748) 2196748..2196990 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
MAK07_RS10955 (2196994) 2196994..2197362 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
MAK07_RS10960 (2197375) 2197375..2197684 - 310 Protein_2128 RusA family crossover junction endodeoxyribonuclease -
MAK07_RS10965 (2197693) 2197693..2197911 - 219 WP_000338531.1 hypothetical protein -
MAK07_RS10970 (2197918) 2197918..2198802 - 885 WP_000148316.1 DnaD domain protein -
MAK07_RS10975 (2198832) 2198832..2199302 - 471 WP_000934764.1 single-stranded DNA-binding protein -
MAK07_RS10980 (2199303) 2199303..2199920 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
MAK07_RS10985 (2200001) 2200001..2200921 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL 2162710..2236213 73503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T234924 WP_001065091.1 NZ_CP091875:c2196576-2196325 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T234924 NZ_LR134151:545925-547247 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAACGGTATTCCGGTGGGATACTGGGAAAAGCATAAAGGTGAAGA
TCGGCTGGAATATCACCCTGACTGGATTGCTGATAGTCAGGGGCGACCCTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTATCGTGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTTTCATGCCGAAAGCCTTGATCCCTTTGATTTACTGGCTGAACTGGGCCGCGACTGTGTGGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCACTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGTGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCTTGCCGCAAGAGGATATGTGCCAGGCTCTGGGTGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGTCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCACTTTTTTAAAGCGCAGATTATTTTTTGGTTGCTGGTCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAATTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACAGGGTGAAATAACCGGGTTAGGGCAACAGGAGATTGAATCTATTATTGAAGAGCTCCTT
GCGGAAACTCCGGGAGTCATTGAGCGTATTACTAGGTTGCTGTCTGATTCGTTTCCGCCTGAATTAGCGGCATGCATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGCTGGAAGGGAGATAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT234924 WP_000028422.1 NZ_CP091875:c2196335-2196153 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT234924 NZ_LR134151:545624-545920 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTACTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAAAGGTTGGGCGTCACCCAGCAGACCTATGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGTATTGAAATGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATGTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGACGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References