Detailed information of TA system TA234921

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2172833..2173140
• Replicon: chromosome
• Accession: NZ_CP091875
• Organism: Staphylococcus aureus strain MN8

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MAK07_RS10790
• Protein ID: WP_011447039.1
• Coordinates: 2172964..2173140 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2172833..2172972 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK07_RS10750 (2168171)	2168171..2168431	+	261	WP_001791826.1	hypothetical protein	-
MAK07_RS10755 (2168484)	2168484..2168834	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
MAK07_RS10760 (2169520)	2169520..2169969	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MAK07_RS10765 (2170064)	2170064..2170399	-	336	Protein_2089	SH3 domain-containing protein	-
MAK07_RS10770 (2171049)	2171049..2171540	-	492	WP_000919350.1	staphylokinase	-
MAK07_RS10775 (2171731)	2171731..2172486	-	756	WP_000861038.1	CHAP domain-containing protein	-
MAK07_RS10780 (2172498)	2172498..2172752	-	255	WP_000611512.1	phage holin	-
MAK07_RS10785 (2172804)	2172804..2172911	+	108	WP_001791821.1	hypothetical protein	-
- (2172833)	2172833..2172972	+	140	NuclAT_0	-	Antitoxin
- (2172833)	2172833..2172972	+	140	NuclAT_0	-	Antitoxin
- (2172833)	2172833..2172972	+	140	NuclAT_0	-	Antitoxin
- (2172833)	2172833..2172972	+	140	NuclAT_0	-	Antitoxin
MAK07_RS10790 (2172964)	2172964..2173140	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MAK07_RS10795 (2173249)	2173249..2174022	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
MAK07_RS10800 (2174443)	2174443..2174817	-	375	WP_000340977.1	hypothetical protein	-
MAK07_RS10805 (2174873)	2174873..2175160	-	288	WP_001040259.1	hypothetical protein	-
MAK07_RS10810 (2175207)	2175207..2175359	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL	2162710..2236213	73503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T234921 WP_011447039.1 NZ_CP091875:c2173140-2172964 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T234921 NZ_LR134151:211123-211398 [Serratia plymuthica]
ATGCTCGTCATCGAATGGAGTCGATCTGCCCGCCAGGACTTGGCGGATATACTGCTTTTCATTGCCAATGACAATCCTCG
GGCAGCCAGAAAAATGAAGGTGTTAATTTCAGAAGCAATTCTTCCTGCCGCTGAACATCCTCATATTTTTCGCCGTGGCA
GGGTTGATGGCACGCACGAAATCATTGTTCATCCCAATTATCTTCTGATCTACCAAGTGGTTGCCGATCGTATCCGGGTG
ATGCGAGTCCTGCATGCACGTCGACGCTATCCCTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT234921 NZ_CP091875:2172833-2172972 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin