Detailed information of TA system TA234917

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1971340..1971520
• Replicon: chromosome
• Accession: NZ_CP091875
• Organism: Staphylococcus aureus strain MN8

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MAK07_RS09460
• Protein ID: WP_001801861.1
• Coordinates: 1971340..1971435 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1971463..1971520 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK07_RS09430	1966484..1967110	+	627	WP_000669038.1	hypothetical protein	-
MAK07_RS09435	1967151..1967495	+	345	WP_000627550.1	DUF3969 family protein	-
MAK07_RS09440	1967593..1968165	+	573	WP_000414222.1	hypothetical protein	-
MAK07_RS09445	1968314..1969681	-	1368	WP_001093574.1	FRG domain-containing protein	-
MAK07_RS09450	1969681..1970250	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MAK07_RS09455	1970443..1970889	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MAK07_RS09460	1971340..1971435	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1971463..1971520	-	58	-	-	Antitoxin
MAK07_RS09465	1971558..1971659	+	102	WP_001791232.1	hypothetical protein	-
MAK07_RS09470	1971834..1972277	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MAK07_RS09475	1972277..1972720	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MAK07_RS09480	1972720..1973162	-	443	Protein_1871	DUF1433 domain-containing protein	-
MAK07_RS09485	1973687..1976107	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / selk	1946529..2146601	200072

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T234917 WP_001801861.1 NZ_CP091875:1971340-1971435 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T234917 NZ_LR134139:c2108475-2108266 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT234917 NZ_CP091875:c1971520-1971463 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin