Detailed information of TA system TA234908

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2570772..2571097
• Replicon: chromosome
• Accession: NZ_CP091872
• Organism: Bacillus sp. Man122

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: MAK48_RS13250
• Protein ID: WP_004398662.1
• Coordinates: 2570772..2570951 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2570875..2571097 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK48_RS13240 (2569998)	2569998..2570135	-	138	WP_003229934.1	hypothetical protein	-
MAK48_RS13245 (2570177)	2570177..2570626	-	450	WP_003229933.1	phage portal protein	-
MAK48_RS13250 (2570772)	2570772..2570951	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
- (2570875)	2570875..2571097	-	223	NuclAT_0	-	Antitoxin
- (2570875)	2570875..2571097	-	223	NuclAT_0	-	Antitoxin
- (2570875)	2570875..2571097	-	223	NuclAT_0	-	Antitoxin
- (2570875)	2570875..2571097	-	223	NuclAT_0	-	Antitoxin
MAK48_RS13255 (2571331)	2571331..2571420	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
MAK48_RS13260 (2571674)	2571674..2572117	-	444	WP_003229930.1	phage tail tube protein	-
MAK48_RS13265 (2572120)	2572120..2573520	-	1401	WP_003229929.1	phage tail sheath family protein	-
MAK48_RS13270 (2573521)	2573521..2573712	-	192	WP_010886574.1	hypothetical protein	-
MAK48_RS13275 (2573709)	2573709..2574146	-	438	WP_003229927.1	hypothetical protein	-
MAK48_RS13280 (2574159)	2574159..2574662	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
MAK48_RS13285 (2574659)	2574659..2575021	-	363	WP_003229925.1	YqbH/XkdH family protein	-
MAK48_RS13290 (2575018)	2575018..2575413	-	396	WP_004398566.1	DUF3199 family protein	-
MAK48_RS13295 (2575417)	2575417..2575728	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2545525..2595636	50111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T234908 WP_004398662.1 NZ_CP091872:2570772-2570951 [Bacillus sp. Man122]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T234908 NZ_LR134136:c3692391-3691972 [Atlantibacter hermannii]
GTGGTCCTGTGGCAATCTGATCTACGCGTCTCATGGCGCGCACAATGGTTTTCGCTCATGCTTCACGGCATTGTTGCGGC
TATTATTTTATTGCTGCCCTGGCCGTTGAGTTACATGCCGCTCTGGCTGATTTTATTATCATTAGTGGTATTTGATTGCG
TGCGCAGCCAACGGCGCATCCATTCACTGCAAGGTGAAGTCAAACTGACAATTGATTATCGGTTGCGCTGGCAAGGTATC
GAGTGGGAACTGACGGCTGCGCCCTGGATGCTGCAAAGCGGCATGTTGCTGCGCTTGCGTCACCCGGATACACATCGCAG
CCAGCATTTATGGCTTGCGGCAGACAGTATGGACGCAGGCGAATGGCGTGATTTACGGCGGATATTAATGCAGCAACCGC
AAAGCGGTCGCCATCCCTGA

Antitoxin

Nucleotide

• Length: 223 bp

>AT234908 NZ_CP091872:c2571097-2570875 [Bacillus sp. Man122]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin