Detailed information of TA system TA234902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 232315..232823
• Replicon: chromosome
• Accession: NZ_CP091864
• Organism: Corynebacterium pseudodiphtheriticum strain PC1130

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: L9H78_RS01005
• Protein ID: WP_249620204.1
• Coordinates: 232315..232575 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L9H78_RS01010
• Protein ID: WP_249620205.1
• Coordinates: 232572..232823 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L9H78_RS00990 (L9H78_00990)	227700..228461	-	762	WP_249620201.1	TetR/AcrR family transcriptional regulator	-
L9H78_RS00995 (L9H78_00995)	228458..230002	-	1545	WP_249620202.1	MFS transporter	-
L9H78_RS01000 (L9H78_01000)	230282..232318	+	2037	WP_249620203.1	BCCT family transporter	-
L9H78_RS01005 (L9H78_01005)	232315..232575	-	261	WP_249620204.1	Txe/YoeB family addiction module toxin	Toxin
L9H78_RS01010 (L9H78_01010)	232572..232823	-	252	WP_249620205.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
L9H78_RS01015 (L9H78_01015)	233031..233978	+	948	WP_249620701.1	hypothetical protein	-
L9H78_RS01020 (L9H78_01020)	234006..235403	-	1398	WP_249620206.1	MFS transporter	-
L9H78_RS01025 (L9H78_01025)	235543..236583	+	1041	WP_249620207.1	hypothetical protein	-
L9H78_RS01030 (L9H78_01030)	236630..237361	-	732	WP_049167580.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	erm(X)	-	223869..246965	23096

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10497.96 Da
• Isoelectric Point: 10.1603

>T234902 WP_249620204.1 NZ_CP091864:c232575-232315 [Corynebacterium pseudodiphtheriticum]
MKLVWTESAWEDYTWWQTEDRKVLKRINRLIKEIQRNGNSGIGKPEPLKHGFQGYWSRRITDEHRLVYKIFGDEVRIASC
RYHYGR

Nucleotide

• Length: 261 bp

>T234902 NZ_LR134136:312968-313336 [Atlantibacter hermannii]
ATGACAATTCAGTTTATCTCAGCGGAAGAGATAATTCGTTTTCATGACAGATTGCTGGCCGTCACGCCAGGCGTACCCGG
TATGGTCGATCCGGGTCGGGCGGAAGCACTGTTATACCGTGTGCTTAACAAATACAAGTATGAAGGCGTTAATGACCTCT
GGCTTTTGGCAGCAATGCACCTGCTGGCTATTTCCCGAGGGCATATCTTCAATGATGGCAATAAACGCACGGCGCTGTTT
ATTACCTTGTTGTTCCTTAAGCGCAATGGGATAACGCTTCCCGCCAACCCGGCATTTGTCGAGTTAACGGTGGCGGCGGC
GGCAGGACAACTTAGCCTTGAAGAGATAGCGCGTCAGTTACGAAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9386.46 Da
• Isoelectric Point: 4.3016

>AT234902 WP_249620205.1 NZ_CP091864:c232823-232572 [Corynebacterium pseudodiphtheriticum]
MKTMSYSDSRAHYAEMLDTVTDDREEVIITRAGHEPVVVVSLDDYESLKETAYLLKSPANARRLLASIEQLENGEGTQRD
LLE

Nucleotide

• Length: 252 bp

>AT234902 NZ_LR134136:312750-312971 [Atlantibacter hermannii]
ATGCAAACCATGAACTATAGCGAAGCGCGCCAGAATCTTGCTGCCGCGCTCGAGACAGCTGCGCTGGGTACGCCTGTTAC
TATCACCCGTCGGGGCCACAAACCTGCGGTAATTATTAGCGCCGAAGAATTCGAACGTTATCAACAAGCAAAGATGGATG
CCGAATTTGCCGCCATCATGGCTATTCATGGCAATGAAATCAGGGAACTTGCCGATAAATGA