Detailed information of TA system TA234874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 3957936..3958477
• Replicon: chromosome
• Accession: NZ_CP091839
• Organism: Escherichia coli strain SWYHX138.261ft

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: A0A246NT41
• Locus tag: L7H22_RS19010
• Protein ID: WP_000615977.1
• Coordinates: 3957936..3958214 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: L7H22_RS19015
• Protein ID: WP_238059060.1
• Coordinates: 3958217..3958477 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L7H22_RS18995 (3955518)	3955518..3956096	+	579	WP_000284050.1	D-sedoheptulose 7-phosphate isomerase	-
L7H22_RS19000 (3956302)	3956302..3957069	+	768	WP_094317940.1	class II glutamine amidotransferase	-
L7H22_RS19005 (3957040)	3957040..3957780	-	741	WP_001225679.1	peptidoglycan meso-diaminopimelic acid protein amidase	-
L7H22_RS19010 (3957936)	3957936..3958214	-	279	WP_000615977.1	type II toxin-antitoxin system mRNA interferase toxin YafQ	Toxin
L7H22_RS19015 (3958217)	3958217..3958477	-	261	WP_238059060.1	type II toxin-antitoxin system antitoxin DinJ	Antitoxin
L7H22_RS19020 (3958687)	3958687..3959436	+	750	WP_000056850.1	C40 family peptidase	-
L7H22_RS19025 (3959612)	3959612..3960109	+	498	WP_187207762.1	REP-associated tyrosine transposase RayT	-
L7H22_RS19030 (3960255)	3960255..3961967	-	1713	Protein_3705	flagellar biosynthesis protein FlhA	-
L7H22_RS19035 (3961939)	3961939..3962724	+	786	WP_000207556.1	putative lateral flagellar export/assembly protein LafU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	gmhA/lpcA	3946236..3960109	13873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10842.67 Da
• Isoelectric Point: 10.0702

>T234874 WP_000615977.1 NZ_CP091839:c3958214-3957936 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNILPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Nucleotide

• Length: 279 bp

>T234874 NZ_LR134095:188822-189088 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9363.76 Da
• Isoelectric Point: 5.8129

>AT234874 WP_238059060.1 NZ_CP091839:c3958477-3958217 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDTDDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT234874 NZ_LR134095:188559-188822 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A246NT41