Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2237850..2238543 Replicon chromosome
Accession NZ_CP091839
Organism Escherichia coli strain SWYHX138.261ft

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L7H22_RS10735 Protein ID WP_000415584.1
Coordinates 2238247..2238543 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L7H22_RS10730 Protein ID WP_000650107.1
Coordinates 2237850..2238245 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H22_RS10720 (2233709) 2233709..2235967 - 2259 WP_238059218.1 DNA topoisomerase IV subunit A -
L7H22_RS10725 (2236105) 2236105..2237717 - 1613 Protein_2099 ABC transporter substrate-binding protein -
L7H22_RS10730 (2237850) 2237850..2238245 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L7H22_RS10735 (2238247) 2238247..2238543 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L7H22_RS10740 (2238748) 2238748..2239230 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L7H22_RS10745 (2239283) 2239283..2239675 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L7H22_RS10750 (2239827) 2239827..2240486 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L7H22_RS10755 (2240483) 2240483..2241832 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L7H22_RS10760 (2241878) 2241878..2242210 - 333 WP_000917684.1 DUF2645 family protein -
L7H22_RS10765 (2242529) 2242529..2243110 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L7H22_RS10770 (2243141) 2243141..2243455 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234868 WP_000415584.1 NZ_CP091839:c2238543-2238247 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234868 NZ_LR134093:c2070924-2070673 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234868 WP_000650107.1 NZ_CP091839:c2238245-2237850 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234868 NZ_LR134093:c2070683-2070501 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References