Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 582504..583142 Replicon chromosome
Accession NZ_CP091839
Organism Escherichia coli strain SWYHX138.261ft

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L7H22_RS02875 Protein ID WP_000813794.1
Coordinates 582504..582680 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L7H22_RS02880 Protein ID WP_001270286.1
Coordinates 582726..583142 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H22_RS02855 (578123) 578123..579298 - 1176 WP_001236265.1 BenE family transporter YdcO -
L7H22_RS02860 (579390) 579390..579926 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L7H22_RS02865 (579999) 579999..581960 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L7H22_RS02870 (582052) 582052..582282 - 231 WP_000494244.1 YncJ family protein -
L7H22_RS02875 (582504) 582504..582680 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L7H22_RS02880 (582726) 582726..583142 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L7H22_RS02885 (583221) 583221..584627 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L7H22_RS02890 (584872) 584872..586017 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L7H22_RS02895 (586035) 586035..587048 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L7H22_RS02900 (587049) 587049..587990 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 576935..578083 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234856 WP_000813794.1 NZ_CP091839:582504-582680 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234856 NZ_LR134092:4145334-4145612 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATATTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234856 WP_001270286.1 NZ_CP091839:582726-583142 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234856 NZ_LR134092:4145071-4145331 [Escherichia coli]
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References