Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3957249..3957790 Replicon chromosome
Accession NZ_CP091836
Organism Escherichia coli strain SWYHX138.33gt

Toxin (Protein)


Gene name yafQ Uniprot ID A0A246NT41
Locus tag L7H17_RS19005 Protein ID WP_000615977.1
Coordinates 3957249..3957527 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag L7H17_RS19010 Protein ID WP_238059060.1
Coordinates 3957530..3957790 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H17_RS18990 (3954831) 3954831..3955409 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
L7H17_RS18995 (3955615) 3955615..3956382 + 768 WP_094317940.1 class II glutamine amidotransferase -
L7H17_RS19000 (3956353) 3956353..3957093 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
L7H17_RS19005 (3957249) 3957249..3957527 - 279 WP_000615977.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
L7H17_RS19010 (3957530) 3957530..3957790 - 261 WP_238059060.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
L7H17_RS19015 (3958000) 3958000..3958749 + 750 WP_000056850.1 C40 family peptidase -
L7H17_RS19020 (3958925) 3958925..3959422 + 498 WP_187207762.1 REP-associated tyrosine transposase RayT -
L7H17_RS19025 (3959568) 3959568..3961280 - 1713 Protein_3704 flagellar biosynthesis protein FlhA -
L7H17_RS19030 (3961252) 3961252..3962037 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / gtrB 3932127..3991476 59349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10842.67 Da        Isoelectric Point: 10.0702

>T234852 WP_000615977.1 NZ_CP091836:c3957527-3957249 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNILPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T234852 NZ_LR134092:2922965-2923072 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9363.76 Da        Isoelectric Point: 5.8129

>AT234852 WP_238059060.1 NZ_CP091836:c3957790-3957530 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDTDDL
FDKLGI

Download         Length: 261 bp

>AT234852 NZ_LR134092:c2922912-2922851 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NT41

Antitoxin

Source ID Structure

References