Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 581635..582273 Replicon chromosome
Accession NZ_CP091836
Organism Escherichia coli strain SWYHX138.33gt

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L7H17_RS02870 Protein ID WP_000813794.1
Coordinates 581635..581811 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L7H17_RS02875 Protein ID WP_001270286.1
Coordinates 581857..582273 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H17_RS02850 (577254) 577254..578429 - 1176 WP_001236265.1 BenE family transporter YdcO -
L7H17_RS02855 (578521) 578521..579057 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L7H17_RS02860 (579130) 579130..581091 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L7H17_RS02865 (581183) 581183..581413 - 231 WP_000494244.1 YncJ family protein -
L7H17_RS02870 (581635) 581635..581811 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L7H17_RS02875 (581857) 581857..582273 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L7H17_RS02880 (582352) 582352..583758 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L7H17_RS02885 (584003) 584003..585148 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L7H17_RS02890 (585166) 585166..586179 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L7H17_RS02895 (586180) 586180..587121 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 576066..577214 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234834 WP_000813794.1 NZ_CP091836:581635-581811 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234834 NZ_LR134091:c2468127-2467885 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234834 WP_001270286.1 NZ_CP091836:581857-582273 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234834 NZ_LR134091:c2468384-2468127 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References