Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 17533..18257 | Replicon | plasmid p1_21223 |
| Accession | NZ_CP091806 | ||
| Organism | Klebsiella quasipneumoniae strain 21223 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A6B7Q840 |
| Locus tag | L7H25_RS25565 | Protein ID | WP_065905253.1 |
| Coordinates | 17533..17844 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L7H25_RS25570 | Protein ID | WP_049010942.1 |
| Coordinates | 17841..18257 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L7H25_RS25505 (L7H25_25500) | 12761..13489 | + | 729 | WP_040107916.1 | plasmid SOS inhibition protein A | - |
| L7H25_RS25510 (L7H25_25505) | 13486..13812 | + | 327 | WP_038992719.1 | hypothetical protein | - |
| L7H25_RS25515 (L7H25_25510) | 13971..14123 | + | 153 | WP_224230667.1 | DUF5431 family protein | - |
| L7H25_RS25520 (L7H25_25515) | 14071..14187 | + | 117 | WP_223176086.1 | type I toxin-antitoxin system Hok family toxin | - |
| L7H25_RS25525 (L7H25_25520) | 14433..14918 | - | 486 | WP_065905260.1 | cytoplasmic protein | - |
| L7H25_RS25530 (L7H25_25525) | 15108..15380 | + | 273 | WP_065905257.1 | hypothetical protein | - |
| L7H25_RS25535 (L7H25_25530) | 15377..15727 | + | 351 | WP_047722605.1 | hypothetical protein | - |
| L7H25_RS25540 (L7H25_25535) | 15742..15804 | + | 63 | Protein_22 | hypothetical protein | - |
| L7H25_RS25545 (L7H25_25540) | 16356..16592 | + | 237 | WP_227524536.1 | single-stranded DNA-binding protein | - |
| L7H25_RS25550 (L7H25_25545) | 16589..16918 | + | 330 | WP_074439645.1 | hypothetical protein | - |
| L7H25_RS25555 (L7H25_25550) | 16979..17191 | + | 213 | WP_065905255.1 | hypothetical protein | - |
| L7H25_RS25560 (L7H25_25555) | 17202..17426 | + | 225 | WP_049157091.1 | hypothetical protein | - |
| L7H25_RS25565 (L7H25_25560) | 17533..17844 | + | 312 | WP_065905253.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| L7H25_RS25570 (L7H25_25565) | 17841..18257 | + | 417 | WP_049010942.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L7H25_RS25575 (L7H25_25570) | 19072..19452 | + | 381 | WP_065905249.1 | hypothetical protein | - |
| L7H25_RS25580 (L7H25_25575) | 19518..19865 | + | 348 | WP_023292162.1 | hypothetical protein | - |
| L7H25_RS25585 (L7H25_25580) | 19954..20184 | + | 231 | WP_065905248.1 | hypothetical protein | - |
| L7H25_RS25590 (L7H25_25585) | 20231..21034 | + | 804 | Protein_32 | N-6 DNA methylase | - |
| L7H25_RS25595 (L7H25_25590) | 21087..21791 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| L7H25_RS25600 (L7H25_25595) | 22665..22952 | - | 288 | WP_009486461.1 | thermonuclease family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..164397 | 164397 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12525.37 Da Isoelectric Point: 9.9242
>T234800 WP_065905253.1 NZ_CP091806:17533-17844 [Klebsiella quasipneumoniae]
VHVISRAPFDEAARHYPNDAVAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAVAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
>T234800 NZ_LR134086:c2058895-2058719 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15438.52 Da Isoelectric Point: 4.4711
>AT234800 WP_049010942.1 NZ_CP091806:17841-18257 [Klebsiella quasipneumoniae]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
>AT234800 NZ_LR134086:2058596-2058651 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|