Detailed information of TA system TA234787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 590432..591729
• Replicon: chromosome
• Accession: NZ_CP091802
• Organism: Prevotella bryantii strain TC1-1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: L6474_RS11990
• Protein ID: WP_094448698.1
• Coordinates: 590764..591729 (+)
• Length: 322 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: L6474_RS11985
• Protein ID: WP_094448697.1
• Coordinates: 590432..590749 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6474_RS11970 (L6474_11970)	589103..589423	+	321	WP_237832310.1	helix-turn-helix transcriptional regulator	-
L6474_RS11975 (L6474_11975)	589820..589927	-	108	Protein_425	site-specific integrase	-
L6474_RS11980 (L6474_11980)	590232..590435	+	204	WP_006281918.1	helix-turn-helix transcriptional regulator	-
L6474_RS11985 (L6474_11985)	590432..590749	+	318	WP_094448697.1	HipA N-terminal domain-containing protein	Antitoxin
L6474_RS11990 (L6474_11990)	590764..591729	+	966	WP_094448698.1	HipA domain-containing protein	Toxin
L6474_RS11995 (L6474_11995)	591974..594133	+	2160	WP_094448699.1	outer membrane beta-barrel family protein	-
L6474_RS12000 (L6474_12000)	594354..594695	+	342	WP_094448700.1	hypothetical protein	-
L6474_RS12005 (L6474_12005)	594891..595226	-	336	WP_094448701.1	single-stranded DNA-binding protein	-
L6474_RS12010 (L6474_12010)	595706..596191	+	486	WP_179226485.1	hypothetical protein	-
L6474_RS12015 (L6474_12015)	596295..596633	+	339	WP_179226486.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (54-276)

Antitoxin

• HipA, N-terminal subdomain 1 (5-101)

Sequences

Toxin

Protein

• Length: 322 a.a.
• Molecular weight: 36849.40 Da
• Isoelectric Point: 7.1612

>T234787 WP_094448698.1 NZ_CP091802:590764-591729 [Prevotella bryantii]
MCKCLYCYKELKEGQKDFHPSCARKFFGTKDVPLLEYKHEELDQLAEQIIRAQTSLTGVQPKLSLNLDKHDGCSRLTIVG
LWGDYIFKPQTENYEQLPENEDLTMHLAEAAKISVVPHSLIRLADGKLGYITKRIDRTENGEKIDMEDMCQLTLHPTEYK
YKGSHEQIAKTILQYSNTPKLDLTNYMQLLLFCFVTGNNDMHLKNFSLYRPAEDYQLTPAYDLLNVAIANPKDKEELALT
LAGKKTKLRLADFLNAAKTMGLEENVVQRLVAGLHKVFPKWQQLIKDSFLSDEQKQTYEELVVTRLDRLKAGQVGKNESK
K

Nucleotide

• Length: 966 bp

>T234787 NZ_LR134085:c1961262-1961110 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11815.80 Da
• Isoelectric Point: 4.3193

>AT234787 WP_094448697.1 NZ_CP091802:590432-590749 [Prevotella bryantii]
MRQAEIYRKDVLAGILTEDGGEYRFCYDEAYLKRGDAQPVSLTLPLQTETFVSPILFPFFDGLIPEGWLLDVALRNTDIS
ILDRMSLLLLCCKECIGSVSVVPIK

Nucleotide

• Length: 318 bp

>AT234787 NZ_LR134085:c1961886-1961287 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA