Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2946020..2946680 Replicon chromosome
Accession NZ_CP091779
Organism Enterobacter mori strain ACYC.E9L

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L6Y89_RS13970 Protein ID WP_237844318.1
Coordinates 2946327..2946680 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L6Y89_RS13965 Protein ID WP_182945657.1
Coordinates 2946020..2946322 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6Y89_RS13945 (L6Y89_13945) 2941056..2942381 + 1326 WP_237844316.1 SidA/IucD/PvdA family monooxygenase -
L6Y89_RS13950 (L6Y89_13950) 2942408..2944597 + 2190 WP_010432111.1 TonB-dependent siderophore receptor -
L6Y89_RS13960 (L6Y89_13960) 2944932..2945891 - 960 WP_237844317.1 zinc-binding alcohol dehydrogenase family protein -
L6Y89_RS13965 (L6Y89_13965) 2946020..2946322 - 303 WP_182945657.1 XRE family transcriptional regulator Antitoxin
L6Y89_RS13970 (L6Y89_13970) 2946327..2946680 - 354 WP_237844318.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6Y89_RS13975 (L6Y89_13975) 2946919..2947869 - 951 WP_010432106.1 HTH-type transcriptional regulator Cbl -
L6Y89_RS13980 (L6Y89_13980) 2947966..2948883 - 918 WP_010432103.1 nitrogen assimilation transcriptional regulator NAC -
L6Y89_RS13990 (L6Y89_13990) 2949413..2950309 - 897 WP_089600501.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13596.46 Da        Isoelectric Point: 8.9623

>T234776 WP_237844318.1 NZ_CP091779:c2946680-2946327 [Enterobacter mori]
VWTINTTDRFDRWFTSLDDTDRASVLAAMLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
MLCAGNKVGSERRFYDEMLLVADREFTYWLNTLKERE

Download         Length: 354 bp

>T234776 NZ_LR134082:2242947-2243234 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.84 Da        Isoelectric Point: 6.2298

>AT234776 WP_182945657.1 NZ_CP091779:c2946322-2946020 [Enterobacter mori]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVHKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT234776 NZ_LR134082:2242708-2242947 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References