Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 739783..740476 Replicon chromosome
Accession NZ_CP091773
Organism Escherichia coli strain SWYH.B349aT

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag L6V99_RS03585 Protein ID WP_000415585.1
Coordinates 739783..740079 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6V99_RS03590 Protein ID WP_000650107.1
Coordinates 740081..740476 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6V99_RS03550 (734917) 734917..735396 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
L6V99_RS03555 (735399) 735399..736109 + 711 WP_000834030.1 hypothetical protein -
L6V99_RS03560 (736116) 736116..736448 + 333 WP_000914690.1 DUF2645 family protein -
L6V99_RS03565 (736494) 736494..737843 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
L6V99_RS03570 (737840) 737840..738499 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
L6V99_RS03575 (738651) 738651..739043 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6V99_RS03580 (739096) 739096..739578 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L6V99_RS03585 (739783) 739783..740079 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
L6V99_RS03590 (740081) 740081..740476 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6V99_RS03595 (740609) 740609..742216 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
L6V99_RS03600 (742354) 742354..744612 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T234739 WP_000415585.1 NZ_CP091773:739783-740079 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234739 NZ_LR134079:c4476447-4476133 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234739 WP_000650107.1 NZ_CP091773:740081-740476 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234739 NZ_LR134079:c4476683-4476450 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References