Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 627618..628206 Replicon chromosome
Accession NZ_CP091770
Organism Helicobacter pylori strain K115

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag L6503_RS02850 Protein ID WP_121293902.1
Coordinates 627618..627899 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag L6503_RS02855 Protein ID WP_140575678.1
Coordinates 627892..628206 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6503_RS02840 (L6503_02840) 623853..625618 + 1766 Protein_555 DUF262 domain-containing protein -
L6503_RS02845 (L6503_02845) 625619..627346 + 1728 WP_237776004.1 type IV secretory system conjugative DNA transfer family protein -
L6503_RS02850 (L6503_02850) 627618..627899 - 282 WP_121293902.1 YafQ family addiction module toxin Toxin
L6503_RS02855 (L6503_02855) 627892..628206 - 315 WP_140575678.1 hypothetical protein Antitoxin
L6503_RS02860 (L6503_02860) 628502..630389 + 1888 Protein_559 relaxase/mobilization nuclease domain-containing protein -
L6503_RS02865 (L6503_02865) 630414..631323 - 910 Protein_560 hypothetical protein -
L6503_RS02870 (L6503_02870) 631355..631639 - 285 WP_121293898.1 hypothetical protein -
L6503_RS02875 (L6503_02875) 631721..632377 - 657 WP_237776005.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10939.84 Da        Isoelectric Point: 9.5726

>T234734 WP_121293902.1 NZ_CP091770:c627899-627618 [Helicobacter pylori]
MFKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELI
LLRLDTHSELFKK

Download         Length: 282 bp

>T234734 NZ_LR134079:3061432-3061539 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGAGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12149.63 Da        Isoelectric Point: 5.2066

>AT234734 WP_140575678.1 NZ_CP091770:c628206-627892 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNV

Download         Length: 315 bp

>AT234734 NZ_LR134079:c3061385-3061319 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References