Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 753657..754350 Replicon chromosome
Accession NZ_CP091756
Organism Escherichia coli strain LC-1302-2020

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6507_RS03655 Protein ID WP_000415584.1
Coordinates 753657..753953 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A8I0NGU8
Locus tag L6507_RS03660 Protein ID WP_021572968.1
Coordinates 753955..754350 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6507_RS03620 (748745) 748745..749059 - 315 WP_000958598.1 putative quinol monooxygenase -
L6507_RS03625 (749090) 749090..749671 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6507_RS03630 (749990) 749990..750322 + 333 WP_000917684.1 DUF2645 family protein -
L6507_RS03635 (750368) 750368..751717 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6507_RS03640 (751714) 751714..752373 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6507_RS03645 (752525) 752525..752917 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6507_RS03650 (752970) 752970..753452 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L6507_RS03655 (753657) 753657..753953 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6507_RS03660 (753955) 753955..754350 + 396 WP_021572968.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6507_RS03665 (754483) 754483..756089 + 1607 Protein_718 ABC transporter substrate-binding protein -
L6507_RS03670 (756227) 756227..758485 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234701 WP_000415584.1 NZ_CP091756:753657-753953 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234701 NZ_LR134075:661350-661664 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14775.16 Da        Isoelectric Point: 8.8481

>AT234701 WP_021572968.1 NZ_CP091756:753955-754350 [Escherichia coli]
MKCPVCHQEEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234701 NZ_LR134075:661661-662077 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure

References