Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 42900..43550 Replicon chromosome
Accession NZ_CP091752
Organism Klebsiella grimontii strain LC-1303-2020

Toxin (Protein)


Gene name higB Uniprot ID A0A9E1GCI7
Locus tag L6506_RS00210 Protein ID WP_024360564.1
Coordinates 42900..43241 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1GGB7
Locus tag L6506_RS00215 Protein ID WP_024360565.1
Coordinates 43251..43550 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6506_RS00195 (L6506_00195) 39133..40452 + 1320 WP_004133107.1 MFS transporter -
L6506_RS00200 (L6506_00200) 40598..41989 + 1392 WP_004126843.1 hexose-6-phosphate:phosphate antiporter -
L6506_RS00205 (L6506_00205) 42201..42653 + 453 WP_049087028.1 DUF1198 domain-containing protein -
L6506_RS00210 (L6506_00210) 42900..43241 + 342 WP_024360564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6506_RS00215 (L6506_00215) 43251..43550 + 300 WP_024360565.1 helix-turn-helix transcriptional regulator Antitoxin
L6506_RS00220 (L6506_00220) 43668..44849 + 1182 WP_082237945.1 purine ribonucleoside efflux pump NepI -
L6506_RS00225 (L6506_00225) 44968..46347 - 1380 WP_004133118.1 carbohydrate porin -
L6506_RS00230 (L6506_00230) 46450..46752 - 303 WP_004855598.1 PTS lactose/cellobiose transporter subunit IIA -
L6506_RS00235 (L6506_00235) 46860..48185 - 1326 WP_004133122.1 PTS sugar transporter subunit IIC -
L6506_RS00240 (L6506_00240) 48197..48508 - 312 WP_004133123.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13091.97 Da        Isoelectric Point: 5.7558

>T234680 WP_024360564.1 NZ_CP091752:42900-43241 [Klebsiella grimontii]
MWDVETTEVFDKWFEAQIEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHRGSPIRAFFVFDPSRRGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T234680 NZ_CP091752:42900-43241 [Klebsiella grimontii]
ATGTGGGATGTTGAAACAACGGAGGTTTTCGACAAGTGGTTTGAGGCGCAGATCGAAGCGCTTAAAGAGGATATGCTCGC
CGCTATGGTGATCTTATCCGAGTATGGCCCCCAACTCGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCTTTTTCGA
ATATGAAAGAGCTGCGCGTTCAGCATCGAGGTAGCCCGATCAGAGCTTTCTTTGTATTTGACCCTTCTCGTCGCGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10994.92 Da        Isoelectric Point: 9.7256

>AT234680 WP_024360565.1 NZ_CP091752:43251-43550 [Klebsiella grimontii]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVVALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT234680 NZ_CP091752:43251-43550 [Klebsiella grimontii]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAAGAAATGCG
CCAGGCTATCGCATTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATTGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGTTATGTTGTAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References