Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 4136427..4137226 | Replicon | chromosome |
Accession | NZ_CP091712 | ||
Organism | Escherichia coli strain KFu014 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | V0SSH7 |
Locus tag | L6L57_RS19730 | Protein ID | WP_000347273.1 |
Coordinates | 4136762..4137226 (+) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | V0TI39 |
Locus tag | L6L57_RS19725 | Protein ID | WP_021547164.1 |
Coordinates | 4136427..4136762 (+) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L6L57_RS19710 (4132212) | 4132212..4132982 | - | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
L6L57_RS19715 (4132998) | 4132998..4134332 | - | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
L6L57_RS19720 (4134707) | 4134707..4136278 | + | 1572 | WP_001273756.1 | galactarate dehydratase | - |
L6L57_RS19725 (4136427) | 4136427..4136762 | + | 336 | WP_021547164.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
L6L57_RS19730 (4136762) | 4136762..4137226 | + | 465 | WP_000347273.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
L6L57_RS19735 (4137281) | 4137281..4138090 | - | 810 | WP_000072171.1 | aga operon transcriptional regulator AgaR | - |
L6L57_RS19740 (4138339) | 4138339..4139619 | + | 1281 | WP_000681958.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
L6L57_RS19745 (4139642) | 4139642..4140115 | + | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
L6L57_RS19750 (4140126) | 4140126..4140905 | + | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
L6L57_RS19755 (4140895) | 4140895..4141773 | + | 879 | WP_001295548.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
L6L57_RS19760 (4141791) | 4141791..4142225 | + | 435 | WP_000948834.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4125944..4137226 | 11282 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17836.25 Da Isoelectric Point: 9.6924
>T234679 WP_000347273.1 NZ_CP091712:4136762-4137226 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
Download Length: 465 bp
>T234679 NZ_LR134031:189359-189466 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12309.86 Da Isoelectric Point: 4.5392
>AT234679 WP_021547164.1 NZ_CP091712:4136427-4136762 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT234679 NZ_LR134031:c189310-189245 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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