Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5577398..5577993 Replicon chromosome
Accession NC_011770
Organism Pseudomonas aeruginosa LESB58

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PLES_RS31640 Protein ID WP_071538299.1
Coordinates 5577715..5577993 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PLES_RS26030 Protein ID WP_003123432.1
Coordinates 5577398..5577703 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLES_RS25995 5572538..5573386 + 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PLES_RS26005 5573553..5574494 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PLES_RS26010 5574611..5575225 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PLES_RS26015 5575267..5575851 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PLES_RS26020 5575892..5576992 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PLES_RS26030 5577398..5577703 - 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
PLES_RS31640 5577715..5577993 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLES_RS26035 5578322..5580550 + 2229 WP_003113525.1 TonB-dependent receptor -
PLES_RS26040 5580620..5581267 - 648 WP_003095021.1 carbonate dehydratase -
PLES_RS26045 5581329..5582567 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T23466 WP_071538299.1 NC_011770:c5577993-5577715 [Pseudomonas aeruginosa LESB58]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T23466 NC_011770:c5577993-5577715 [Pseudomonas aeruginosa LESB58]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT23466 WP_003123432.1 NC_011770:c5577703-5577398 [Pseudomonas aeruginosa LESB58]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT23466 NC_011770:c5577703-5577398 [Pseudomonas aeruginosa LESB58]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References