Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 43869..44108 | Replicon | plasmid pKGu016_1 |
| Accession | NZ_CP091705 | ||
| Organism | Escherichia coli strain KGu016 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | A0A762TWR7 |
| Locus tag | L6L59_RS24910 | Protein ID | WP_023144756.1 |
| Coordinates | 43869..44003 (-) | Length | 45 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 44048..44108 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L59_RS24870 (39890) | 39890..40291 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| L6L59_RS24875 (40224) | 40224..40481 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| L6L59_RS24880 (40574) | 40574..41227 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| L6L59_RS24885 (41325) | 41325..41465 | - | 141 | WP_001333237.1 | hypothetical protein | - |
| L6L59_RS24890 (42166) | 42166..43014 | - | 849 | WP_139471275.1 | incFII family plasmid replication initiator RepA | - |
| L6L59_RS24895 (43007) | 43007..43081 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| L6L59_RS24905 (43318) | 43318..43572 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| L6L59_RS24910 (43869) | 43869..44003 | - | 135 | WP_023144756.1 | Hok/Gef family protein | Toxin |
| - (44048) | 44048..44108 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (44048) | 44048..44108 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (44048) | 44048..44108 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (44048) | 44048..44108 | + | 61 | NuclAT_0 | - | Antitoxin |
| L6L59_RS24915 (44075) | 44075..44361 | - | 287 | Protein_58 | DUF2726 domain-containing protein | - |
| L6L59_RS24920 (44874) | 44874..45086 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| L6L59_RS24925 (45217) | 45217..45777 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| L6L59_RS24930 (45832) | 45832..46578 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(B) | - | 1..100940 | 100940 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 45 a.a. Molecular weight: 4896.90 Da Isoelectric Point: 7.7209
>T234647 WP_023144756.1 NZ_CP091705:c44003-43869 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA
Download Length: 135 bp
>T234647 NZ_LR133996:80177-80488 [Shimwellia blattae]
ATGCATATTATATCAAGAGCGCCGTTCGATACCGCGACCAAAATATTCCCTAATCAGGCTGCTGCACTTGATGATCTTTA
CCGGGTTCTGAAACGTGAGAATTATCGCTCACCGGATGAGATGAGAATGCAATTTCCCAGCCTGGACCGGATGAAGCTCC
GGGAAAAATGGTGGGTTATTGATGTGGGTGGTGGTCAGCTAAGGGTGATGTTCTTTGCTGATTTTGAACGGGGAAAGTTG
TTCATCAAGCATATTTCTACCCATGCTGAATACGACAAGCTGACGGACTATTACCGGAGGAACAAAGAGTGA
ATGCATATTATATCAAGAGCGCCGTTCGATACCGCGACCAAAATATTCCCTAATCAGGCTGCTGCACTTGATGATCTTTA
CCGGGTTCTGAAACGTGAGAATTATCGCTCACCGGATGAGATGAGAATGCAATTTCCCAGCCTGGACCGGATGAAGCTCC
GGGAAAAATGGTGGGTTATTGATGTGGGTGGTGGTCAGCTAAGGGTGATGTTCTTTGCTGATTTTGAACGGGGAAAGTTG
TTCATCAAGCATATTTCTACCCATGCTGAATACGACAAGCTGACGGACTATTACCGGAGGAACAAAGAGTGA
Antitoxin
Download Length: 61 bp
>AT234647 NZ_CP091705:44048-44108 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
