Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 746780..747473 Replicon chromosome
Accession NZ_CP091704
Organism Escherichia coli strain KGu016

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L59_RS03580 Protein ID WP_000415584.1
Coordinates 746780..747076 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L59_RS03585 Protein ID WP_000650107.1
Coordinates 747078..747473 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L59_RS03545 (741829) 741829..742143 - 315 WP_000958598.1 putative quinol monooxygenase -
L6L59_RS03550 (742174) 742174..742755 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L59_RS03555 (743113) 743113..743442 + 330 WP_001551659.1 DUF2645 family protein -
L6L59_RS03560 (743491) 743491..744840 - 1350 WP_001551658.1 quorum sensing histidine kinase QseC -
L6L59_RS03565 (744837) 744837..745496 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L59_RS03570 (745648) 745648..746040 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L59_RS03575 (746093) 746093..746575 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L59_RS03580 (746780) 746780..747076 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L59_RS03585 (747078) 747078..747473 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L59_RS03590 (747606) 747606..749213 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L59_RS03595 (749351) 749351..751609 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234619 WP_000415584.1 NZ_CP091704:746780-747076 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234619 NZ_LR132067:470695-471036 [Enterococcus faecium]
GTGTCAGGAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTTATTTTGATCCCTCATTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234619 WP_000650107.1 NZ_CP091704:747078-747473 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234619 NZ_LR132067:470465-470695 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGACGATGGTACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References