Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4044833..4045526 Replicon chromosome
Accession NZ_CP091700
Organism Escherichia coli strain KFu019

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L55_RS20825 Protein ID WP_000415584.1
Coordinates 4045230..4045526 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L55_RS20820 Protein ID WP_000650107.1
Coordinates 4044833..4045228 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L55_RS20810 (4040697) 4040697..4042955 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
L6L55_RS20815 (4043093) 4043093..4044700 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L55_RS20820 (4044833) 4044833..4045228 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L55_RS20825 (4045230) 4045230..4045526 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L55_RS20830 (4045731) 4045731..4046213 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L55_RS20835 (4046266) 4046266..4046658 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L55_RS20840 (4046810) 4046810..4047469 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L55_RS20845 (4047466) 4047466..4048815 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6L55_RS20850 (4048861) 4048861..4049193 - 333 WP_000917684.1 DUF2645 family protein -
L6L55_RS20855 (4049512) 4049512..4050093 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L55_RS20860 (4050124) 4050124..4050438 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234588 WP_000415584.1 NZ_CP091700:c4045526-4045230 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234588 NZ_LR130562:c4445228-4444878 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234588 WP_000650107.1 NZ_CP091700:c4045228-4044833 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234588 NZ_LR130562:c4445473-4445222 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References