Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-orzP/Ldr(toxin)
Location 1998404..1998625 Replicon chromosome
Accession NZ_CP091700
Organism Escherichia coli strain KFu019

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag L6L55_RS10585 Protein ID WP_000170955.1
Coordinates 1998404..1998511 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name orzP
Locus tag -
Coordinates 1998559..1998625 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L55_RS10560 (1994248) 1994248..1995330 + 1083 WP_000804726.1 peptide chain release factor 1 -
L6L55_RS10565 (1995330) 1995330..1996163 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
L6L55_RS10570 (1996160) 1996160..1996552 + 393 WP_000200374.1 invasion regulator SirB2 -
L6L55_RS10575 (1996556) 1996556..1997365 + 810 WP_001257044.1 invasion regulator SirB1 -
L6L55_RS10580 (1997401) 1997401..1998255 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
L6L55_RS10585 (1998404) 1998404..1998511 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (1998561) 1998561..1998624 + 64 NuclAT_39 - -
- (1998561) 1998561..1998624 + 64 NuclAT_39 - -
- (1998561) 1998561..1998624 + 64 NuclAT_39 - -
- (1998561) 1998561..1998624 + 64 NuclAT_39 - -
- (1998561) 1998561..1998624 + 64 NuclAT_42 - -
- (1998561) 1998561..1998624 + 64 NuclAT_42 - -
- (1998561) 1998561..1998624 + 64 NuclAT_42 - -
- (1998561) 1998561..1998624 + 64 NuclAT_42 - -
- (1998561) 1998561..1998624 + 64 NuclAT_45 - -
- (1998561) 1998561..1998624 + 64 NuclAT_45 - -
- (1998561) 1998561..1998624 + 64 NuclAT_45 - -
- (1998561) 1998561..1998624 + 64 NuclAT_45 - -
- (1998561) 1998561..1998624 + 64 NuclAT_48 - -
- (1998561) 1998561..1998624 + 64 NuclAT_48 - -
- (1998561) 1998561..1998624 + 64 NuclAT_48 - -
- (1998561) 1998561..1998624 + 64 NuclAT_48 - -
- (1998561) 1998561..1998624 + 64 NuclAT_55 - -
- (1998561) 1998561..1998624 + 64 NuclAT_55 - -
- (1998561) 1998561..1998624 + 64 NuclAT_55 - -
- (1998561) 1998561..1998624 + 64 NuclAT_55 - -
- (1998561) 1998561..1998624 + 64 NuclAT_58 - -
- (1998561) 1998561..1998624 + 64 NuclAT_58 - -
- (1998561) 1998561..1998624 + 64 NuclAT_58 - -
- (1998561) 1998561..1998624 + 64 NuclAT_58 - -
- (1998559) 1998559..1998625 + 67 NuclAT_15 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_15 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_15 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_15 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_18 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_18 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_18 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_18 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_21 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_21 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_21 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_21 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_24 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_24 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_24 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_24 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_27 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_27 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_27 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_27 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_30 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_30 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_30 - Antitoxin
- (1998559) 1998559..1998625 + 67 NuclAT_30 - Antitoxin
L6L55_RS10590 (1998939) 1998939..1999046 - 108 WP_000170963.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1999094) 1999094..1999159 + 66 NuclAT_37 - -
- (1999094) 1999094..1999159 + 66 NuclAT_37 - -
- (1999094) 1999094..1999159 + 66 NuclAT_37 - -
- (1999094) 1999094..1999159 + 66 NuclAT_37 - -
- (1999094) 1999094..1999159 + 66 NuclAT_40 - -
- (1999094) 1999094..1999159 + 66 NuclAT_40 - -
- (1999094) 1999094..1999159 + 66 NuclAT_40 - -
- (1999094) 1999094..1999159 + 66 NuclAT_40 - -
- (1999094) 1999094..1999159 + 66 NuclAT_43 - -
- (1999094) 1999094..1999159 + 66 NuclAT_43 - -
- (1999094) 1999094..1999159 + 66 NuclAT_43 - -
- (1999094) 1999094..1999159 + 66 NuclAT_43 - -
- (1999094) 1999094..1999159 + 66 NuclAT_46 - -
- (1999094) 1999094..1999159 + 66 NuclAT_46 - -
- (1999094) 1999094..1999159 + 66 NuclAT_46 - -
- (1999094) 1999094..1999159 + 66 NuclAT_46 - -
- (1999094) 1999094..1999159 + 66 NuclAT_53 - -
- (1999094) 1999094..1999159 + 66 NuclAT_53 - -
- (1999094) 1999094..1999159 + 66 NuclAT_53 - -
- (1999094) 1999094..1999159 + 66 NuclAT_53 - -
- (1999094) 1999094..1999159 + 66 NuclAT_56 - -
- (1999094) 1999094..1999159 + 66 NuclAT_56 - -
- (1999094) 1999094..1999159 + 66 NuclAT_56 - -
- (1999094) 1999094..1999159 + 66 NuclAT_56 - -
- (1999095) 1999095..1999160 + 66 NuclAT_16 - -
- (1999095) 1999095..1999160 + 66 NuclAT_16 - -
- (1999095) 1999095..1999160 + 66 NuclAT_16 - -
- (1999095) 1999095..1999160 + 66 NuclAT_16 - -
- (1999095) 1999095..1999160 + 66 NuclAT_19 - -
- (1999095) 1999095..1999160 + 66 NuclAT_19 - -
- (1999095) 1999095..1999160 + 66 NuclAT_19 - -
- (1999095) 1999095..1999160 + 66 NuclAT_19 - -
- (1999095) 1999095..1999160 + 66 NuclAT_22 - -
- (1999095) 1999095..1999160 + 66 NuclAT_22 - -
- (1999095) 1999095..1999160 + 66 NuclAT_22 - -
- (1999095) 1999095..1999160 + 66 NuclAT_22 - -
- (1999095) 1999095..1999160 + 66 NuclAT_25 - -
- (1999095) 1999095..1999160 + 66 NuclAT_25 - -
- (1999095) 1999095..1999160 + 66 NuclAT_25 - -
- (1999095) 1999095..1999160 + 66 NuclAT_25 - -
- (1999095) 1999095..1999160 + 66 NuclAT_28 - -
- (1999095) 1999095..1999160 + 66 NuclAT_28 - -
- (1999095) 1999095..1999160 + 66 NuclAT_28 - -
- (1999095) 1999095..1999160 + 66 NuclAT_28 - -
- (1999095) 1999095..1999160 + 66 NuclAT_31 - -
- (1999095) 1999095..1999160 + 66 NuclAT_31 - -
- (1999095) 1999095..1999160 + 66 NuclAT_31 - -
- (1999095) 1999095..1999160 + 66 NuclAT_31 - -
L6L55_RS10595 (1999474) 1999474..1999581 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1999629) 1999629..1999694 + 66 NuclAT_38 - -
- (1999629) 1999629..1999694 + 66 NuclAT_38 - -
- (1999629) 1999629..1999694 + 66 NuclAT_38 - -
- (1999629) 1999629..1999694 + 66 NuclAT_38 - -
- (1999629) 1999629..1999694 + 66 NuclAT_41 - -
- (1999629) 1999629..1999694 + 66 NuclAT_41 - -
- (1999629) 1999629..1999694 + 66 NuclAT_41 - -
- (1999629) 1999629..1999694 + 66 NuclAT_41 - -
- (1999629) 1999629..1999694 + 66 NuclAT_44 - -
- (1999629) 1999629..1999694 + 66 NuclAT_44 - -
- (1999629) 1999629..1999694 + 66 NuclAT_44 - -
- (1999629) 1999629..1999694 + 66 NuclAT_44 - -
- (1999629) 1999629..1999694 + 66 NuclAT_47 - -
- (1999629) 1999629..1999694 + 66 NuclAT_47 - -
- (1999629) 1999629..1999694 + 66 NuclAT_47 - -
- (1999629) 1999629..1999694 + 66 NuclAT_47 - -
- (1999629) 1999629..1999694 + 66 NuclAT_54 - -
- (1999629) 1999629..1999694 + 66 NuclAT_54 - -
- (1999629) 1999629..1999694 + 66 NuclAT_54 - -
- (1999629) 1999629..1999694 + 66 NuclAT_54 - -
- (1999629) 1999629..1999694 + 66 NuclAT_57 - -
- (1999629) 1999629..1999694 + 66 NuclAT_57 - -
- (1999629) 1999629..1999694 + 66 NuclAT_57 - -
- (1999629) 1999629..1999694 + 66 NuclAT_57 - -
- (1999630) 1999630..1999695 + 66 NuclAT_17 - -
- (1999630) 1999630..1999695 + 66 NuclAT_17 - -
- (1999630) 1999630..1999695 + 66 NuclAT_17 - -
- (1999630) 1999630..1999695 + 66 NuclAT_17 - -
- (1999630) 1999630..1999695 + 66 NuclAT_20 - -
- (1999630) 1999630..1999695 + 66 NuclAT_20 - -
- (1999630) 1999630..1999695 + 66 NuclAT_20 - -
- (1999630) 1999630..1999695 + 66 NuclAT_20 - -
- (1999630) 1999630..1999695 + 66 NuclAT_23 - -
- (1999630) 1999630..1999695 + 66 NuclAT_23 - -
- (1999630) 1999630..1999695 + 66 NuclAT_23 - -
- (1999630) 1999630..1999695 + 66 NuclAT_23 - -
- (1999630) 1999630..1999695 + 66 NuclAT_26 - -
- (1999630) 1999630..1999695 + 66 NuclAT_26 - -
- (1999630) 1999630..1999695 + 66 NuclAT_26 - -
- (1999630) 1999630..1999695 + 66 NuclAT_26 - -
- (1999630) 1999630..1999695 + 66 NuclAT_29 - -
- (1999630) 1999630..1999695 + 66 NuclAT_29 - -
- (1999630) 1999630..1999695 + 66 NuclAT_29 - -
- (1999630) 1999630..1999695 + 66 NuclAT_29 - -
- (1999630) 1999630..1999695 + 66 NuclAT_32 - -
- (1999630) 1999630..1999695 + 66 NuclAT_32 - -
- (1999630) 1999630..1999695 + 66 NuclAT_32 - -
- (1999630) 1999630..1999695 + 66 NuclAT_32 - -
L6L55_RS10600 (1999985) 1999985..2001085 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
L6L55_RS10605 (2001355) 2001355..2001585 + 231 WP_001146444.1 putative cation transport regulator ChaB -
L6L55_RS10610 (2001743) 2001743..2002438 + 696 WP_001297117.1 glutathione-specific gamma-glutamylcyclotransferase -
L6L55_RS10615 (2002482) 2002482..2002835 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T234568 WP_000170955.1 NZ_CP091700:c1998511-1998404 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T234568 NZ_LR130562:c842584-842210 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGAACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 67 bp

>AT234568 NZ_CP091700:1998559-1998625 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References