Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1305689..1306327 Replicon chromosome
Accession NZ_CP091691
Organism Escherichia coli strain KMi006

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag L6L65_RS06280 Protein ID WP_001447010.1
Coordinates 1306151..1306327 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L65_RS06275 Protein ID WP_001270286.1
Coordinates 1305689..1306105 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L65_RS06255 (1300841) 1300841..1301782 - 942 WP_001251304.1 ABC transporter permease -
L6L65_RS06260 (1301783) 1301783..1302796 - 1014 WP_000220395.1 ABC transporter ATP-binding protein -
L6L65_RS06265 (1302814) 1302814..1303959 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L6L65_RS06270 (1304204) 1304204..1305610 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6L65_RS06275 (1305689) 1305689..1306105 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L65_RS06280 (1306151) 1306151..1306327 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L65_RS06285 (1306549) 1306549..1306779 + 231 WP_000494244.1 YncJ family protein -
L6L65_RS06290 (1306871) 1306871..1308832 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L65_RS06295 (1308905) 1308905..1309441 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6L65_RS06300 (1309494) 1309494..1310708 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1310748..1311896 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T234532 WP_001447010.1 NZ_CP091691:c1306327-1306151 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234532 NZ_LR130555:242474-242581 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234532 WP_001270286.1 NZ_CP091691:c1306105-1305689 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234532 NZ_LR130555:c242425-242362 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References