Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3978800..3979493 Replicon chromosome
Accession NZ_CP091682
Organism Escherichia coli strain KKo003

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L54_RS19405 Protein ID WP_000415584.1
Coordinates 3979197..3979493 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L54_RS19400 Protein ID WP_000650107.1
Coordinates 3978800..3979195 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L54_RS19390 (3974664) 3974664..3976922 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
L6L54_RS19395 (3977060) 3977060..3978667 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L54_RS19400 (3978800) 3978800..3979195 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L54_RS19405 (3979197) 3979197..3979493 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L54_RS19410 (3979698) 3979698..3980180 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L54_RS19415 (3980233) 3980233..3980625 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L54_RS19420 (3980777) 3980777..3981436 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L54_RS19425 (3981433) 3981433..3982782 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6L54_RS19430 (3982828) 3982828..3983160 - 333 WP_000917685.1 DUF2645 family protein -
L6L54_RS19435 (3983479) 3983479..3984060 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L54_RS19440 (3984091) 3984091..3984405 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3970337..3979493 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234513 WP_000415584.1 NZ_CP091682:c3979493-3979197 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234513 NZ_LR130552:1868029-1868280 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234513 WP_000650107.1 NZ_CP091682:c3979195-3978800 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234513 NZ_LR130552:1868277-1868531 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References