Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1223126..1223958 | Replicon | chromosome |
| Accession | NC_011761 | ||
| Organism | Acidithiobacillus ferrooxidans ATCC 23270 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | B7J9L0 |
| Locus tag | AFE_RS06615 | Protein ID | WP_009569577.1 |
| Coordinates | 1223126..1223632 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | B7J9L1 |
| Locus tag | AFE_RS06620 | Protein ID | WP_009569578.1 |
| Coordinates | 1223629..1223958 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFE_RS06590 | 1218134..1218523 | + | 390 | WP_009565421.1 | holo-ACP synthase | - |
| AFE_RS06595 | 1218527..1219849 | + | 1323 | WP_012607056.1 | UDP-glucose/GDP-mannose dehydrogenase family protein | - |
| AFE_RS06600 | 1219830..1220801 | + | 972 | WP_049759457.1 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | - |
| AFE_RS06605 | 1220803..1221573 | + | 771 | WP_012536502.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| AFE_RS06610 | 1221566..1222408 | + | 843 | WP_012536503.1 | Hsp33 family molecular chaperone HslO | - |
| AFE_RS06615 | 1223126..1223632 | - | 507 | WP_009569577.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| AFE_RS06620 | 1223629..1223958 | - | 330 | WP_009569578.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| AFE_RS16455 | 1224245..1224388 | + | 144 | WP_009569579.1 | hypothetical protein | - |
| AFE_RS06625 | 1224415..1224681 | - | 267 | WP_012536504.1 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| AFE_RS06630 | 1225026..1225520 | - | 495 | WP_009565062.1 | GNAT family N-acetyltransferase | - |
| AFE_RS06635 | 1225517..1225789 | - | 273 | WP_012536505.1 | DUF1778 domain-containing protein | - |
| AFE_RS06640 | 1225870..1226082 | - | 213 | WP_009562915.1 | hypothetical protein | - |
| AFE_RS06645 | 1226250..1226466 | - | 217 | Protein_1270 | hypothetical protein | - |
| AFE_RS06650 | 1226866..1227687 | - | 822 | WP_012536506.1 | UDP-2,3-diacylglucosamine diphosphatase | - |
| AFE_RS06655 | 1227928..1228173 | + | 246 | WP_009568482.1 | DUF2934 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 19373.17 Da Isoelectric Point: 9.9366
>T23451 WP_009569577.1 NC_011761:c1223632-1223126 [Acidithiobacillus ferrooxidans ATCC 23270]
MSSSKLAPLVIHGWTVFAHPLFLAHIETLAQQVEAFKKKDPVGYVKKNANKRLAAIIKLAFDAIPQDPTRPEYRQGNTLG
EDHKHWFRAKFFQQYRLFFRYHAPSKVIVLAWVNDEDTKRAYESSDDAYRVFRKMLESGRPPDDWNQLLAEACAEGQRLQ
RFAAGIAP
MSSSKLAPLVIHGWTVFAHPLFLAHIETLAQQVEAFKKKDPVGYVKKNANKRLAAIIKLAFDAIPQDPTRPEYRQGNTLG
EDHKHWFRAKFFQQYRLFFRYHAPSKVIVLAWVNDEDTKRAYESSDDAYRVFRKMLESGRPPDDWNQLLAEACAEGQRLQ
RFAAGIAP
Download Length: 507 bp
>T23451 NC_011761:c1223632-1223126 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGAGCTCGAGCAAGCTCGCGCCCTTGGTCATTCATGGCTGGACGGTTTTTGCCCACCCGCTATTCCTCGCGCATATTGA
GACCTTGGCCCAGCAGGTCGAGGCCTTCAAGAAAAAGGATCCCGTCGGATACGTGAAAAAGAACGCCAATAAGCGACTGG
CGGCGATCATCAAACTGGCGTTCGACGCCATCCCGCAAGACCCGACACGGCCAGAGTACCGTCAAGGCAACACCCTCGGT
GAAGATCACAAGCACTGGTTCCGCGCCAAGTTTTTCCAGCAATACCGGCTGTTCTTCCGCTACCACGCGCCGAGCAAGGT
GATCGTGCTCGCCTGGGTCAATGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGACGACGCCTATCGGGTGTTCCGAA
AGATGCTGGAAAGCGGCCGTCCTCCGGATGACTGGAACCAGTTGCTGGCCGAGGCATGCGCCGAGGGGCAGCGACTACAG
CGATTCGCTGCTGGCATTGCACCGTAA
ATGAGCTCGAGCAAGCTCGCGCCCTTGGTCATTCATGGCTGGACGGTTTTTGCCCACCCGCTATTCCTCGCGCATATTGA
GACCTTGGCCCAGCAGGTCGAGGCCTTCAAGAAAAAGGATCCCGTCGGATACGTGAAAAAGAACGCCAATAAGCGACTGG
CGGCGATCATCAAACTGGCGTTCGACGCCATCCCGCAAGACCCGACACGGCCAGAGTACCGTCAAGGCAACACCCTCGGT
GAAGATCACAAGCACTGGTTCCGCGCCAAGTTTTTCCAGCAATACCGGCTGTTCTTCCGCTACCACGCGCCGAGCAAGGT
GATCGTGCTCGCCTGGGTCAATGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGACGACGCCTATCGGGTGTTCCGAA
AGATGCTGGAAAGCGGCCGTCCTCCGGATGACTGGAACCAGTTGCTGGCCGAGGCATGCGCCGAGGGGCAGCGACTACAG
CGATTCGCTGCTGGCATTGCACCGTAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12107.54 Da Isoelectric Point: 4.3141
>AT23451 WP_009569578.1 NC_011761:c1223958-1223629 [Acidithiobacillus ferrooxidans ATCC 23270]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEDSEEDDPVLGQFLGFLARDIATHPERLQA
IDVSFVQRLQSLTGGIEVDLDAPLSADDE
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEDSEEDDPVLGQFLGFLARDIATHPERLQA
IDVSFVQRLQSLTGGIEVDLDAPLSADDE
Download Length: 330 bp
>AT23451 NC_011761:c1223958-1223629 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGCTGCCACCCTCGAAGTCGAATCCACGCTGACTGACCGCTACCAAACCACGGTGCCGGAGACCGTCCGCCGGGCCCT
CCGGCTGGGCAAGCGCGACAAGATCCACTACACCATCCGCCCCGGTGGCGAGGTCGTGCTGACGCGCGCCGAGGACTCCG
AGGAAGACGATCCGGTGCTCGGTCAGTTCCTGGGCTTCCTGGCCCGCGACATCGCCACGCATCCAGAGCGCCTGCAGGCC
ATCGATGTCAGCTTCGTGCAGCGCCTCCAATCGCTGACCGGCGGCATCGAAGTCGATCTCGATGCCCCCTTGTCTGCGGA
CGATGAATGA
ATGGCTGCCACCCTCGAAGTCGAATCCACGCTGACTGACCGCTACCAAACCACGGTGCCGGAGACCGTCCGCCGGGCCCT
CCGGCTGGGCAAGCGCGACAAGATCCACTACACCATCCGCCCCGGTGGCGAGGTCGTGCTGACGCGCGCCGAGGACTCCG
AGGAAGACGATCCGGTGCTCGGTCAGTTCCTGGGCTTCCTGGCCCGCGACATCGCCACGCATCCAGAGCGCCTGCAGGCC
ATCGATGTCAGCTTCGTGCAGCGCCTCCAATCGCTGACCGGCGGCATCGAAGTCGATCTCGATGCCCCCTTGTCTGCGGA
CGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|