Detailed information of TA system TA234495

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 690912..691170
• Replicon: chromosome
• Accession: NZ_CP091682
• Organism: Escherichia coli strain KKo003

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: L6L54_RS03340
• Protein ID: WP_000809168.1
• Coordinates: 690912..691064 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	691113..691170 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L54_RS03320	686157..686870	-	714	WP_001102391.1	acidic protein MsyB	-
L6L54_RS03325	686896..687300	-	405	WP_000843687.1	DUF2541 family protein	-
L6L54_RS03330	687672..689588	+	1917	WP_000516135.1	molecular chaperone DnaK	-
L6L54_RS03335	689677..690807	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
L6L54_RS03340	690912..691064	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	691113..691170	+	58	-	-	Antitoxin
L6L54_RS03345	691679..692440	+	762	WP_001274832.1	outer membrane protein OmpK	-
L6L54_RS03350	692460..693953	+	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
L6L54_RS03355	694082..695341	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T234495 WP_000809168.1 NZ_CP091682:c691064-690912 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T234495 NZ_LR130548:351689-352036 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT234495 NZ_CP091682:691113-691170 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin