Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3734249..3734942 Replicon chromosome
Accession NZ_CP091677
Organism Escherichia coli strain KFu022

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L66_RS18185 Protein ID WP_000415584.1
Coordinates 3734646..3734942 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L66_RS18180 Protein ID WP_000650107.1
Coordinates 3734249..3734644 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L66_RS18170 (3730113) 3730113..3732371 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
L6L66_RS18175 (3732509) 3732509..3734116 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L66_RS18180 (3734249) 3734249..3734644 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L66_RS18185 (3734646) 3734646..3734942 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L66_RS18190 (3735147) 3735147..3735629 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L66_RS18195 (3735682) 3735682..3736074 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L66_RS18200 (3736226) 3736226..3736885 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L66_RS18205 (3736882) 3736882..3738231 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6L66_RS18210 (3738277) 3738277..3738609 - 333 WP_000917684.1 DUF2645 family protein -
L6L66_RS18215 (3738928) 3738928..3739509 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L66_RS18220 (3739540) 3739540..3739854 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234479 WP_000415584.1 NZ_CP091677:c3734942-3734646 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234479 NZ_LR130545:c3745836-3745534 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234479 WP_000650107.1 NZ_CP091677:c3734644-3734249 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234479 NZ_LR130545:c3745498-3745157 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References