Detailed information of TA system TA234462

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1943029..1943400
• Replicon: chromosome
• Accession: NZ_CP091677
• Organism: Escherichia coli strain KFu022

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: L6L66_RS09620
• Protein ID: WP_053889809.1
• Coordinates: 1943206..1943400 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1943029..1943207 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L66_RS24150 (1938781)	1938781..1938954	+	174	WP_001296046.1	protein YnaL	-
L6L66_RS09595 (1938984)	1938984..1940357	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
L6L66_RS09600 (1940486)	1940486..1941421	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
L6L66_RS09605 (1941473)	1941473..1942708	-	1236	WP_000040852.1	site-specific integrase	-
L6L66_RS09610 (1942710)	1942710..1942925	-	216	WP_000079604.1	excisionase XisR	-
- (1943029)	1943029..1943207	+	179	NuclAT_0	-	Antitoxin
- (1943029)	1943029..1943207	+	179	NuclAT_0	-	Antitoxin
- (1943029)	1943029..1943207	+	179	NuclAT_0	-	Antitoxin
- (1943029)	1943029..1943207	+	179	NuclAT_0	-	Antitoxin
L6L66_RS09615 (1943004)	1943004..1943213	-	210	WP_137463211.1	double-strand break reduction protein RcbA	-
L6L66_RS09620 (1943206)	1943206..1943400	-	195	WP_053889809.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
L6L66_RS09625 (1943457)	1943457..1944266	-	810	WP_000166319.1	recombination protein RecT	-
L6L66_RS09630 (1944259)	1944259..1946859	-	2601	WP_073520447.1	exodeoxyribonuclease VIII	-
L6L66_RS09635 (1946961)	1946961..1947236	-	276	WP_000632297.1	protein RacC	-
L6L66_RS09640 (1947311)	1947311..1947481	-	171	WP_001352098.1	YdaE family protein	-
L6L66_RS09645 (1947481)	1947481..1947702	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1941473..1968296	26823

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7032.91 Da
• Isoelectric Point: 8.9538

>T234462 WP_053889809.1 NZ_CP091677:c1943400-1943206 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGIHV

Nucleotide

• Length: 195 bp

>T234462 NZ_LR130544:4128805-4129023 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT234462 NZ_CP091677:1943029-1943207 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTTGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin