Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 85685..86293 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name higB Uniprot ID A0A2W1K1W3
Locus tag AFE_RS00435 Protein ID WP_012535782.1
Coordinates 85685..85960 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AFE_RS00440 Protein ID WP_009566298.1
Coordinates 85976..86293 (+) Length 106 a.a.

Genomic Context

AFE_RS00395AFE_RS00400AFE_RS00405AFE_RS00420AFE_RS00425AFE_RS00430AFE_RS00435AFE_RS00440AFE_RS00445AFE_RS00450AFE_RS16560AFE_RS00460AFE_RS00465AFE_RS00470AFE_RS00475
Location: 81463..82503 (1041 bp)
Type: Others
Protein ID: WP_012535779.1
Location: 82571..83497 (927 bp)
Type: Others
Protein ID: WP_012535780.1
Location: 83502..83858 (357 bp)
Type: Others
Protein ID: Protein_81
Location: 84598..84819 (222 bp)
Type: Others
Protein ID: WP_009566302.1
Location: 84819..85232 (414 bp)
Type: Others
Protein ID: WP_009566301.1
Location: 85229..85519 (291 bp)
Type: Others
Protein ID: WP_009566300.1
Location: 85685..85960 (276 bp)
Type: Toxin
Protein ID: WP_012535782.1
Location: 85976..86293 (318 bp)
Type: Antitoxin
Protein ID: WP_009566298.1
Location: 86308..86487 (180 bp)
Type: Others
Protein ID: WP_009566297.1
Location: 86907..88070 (1164 bp)
Type: Others
Protein ID: WP_009566294.1
Location: 88367..88633 (267 bp)
Type: Others
Protein ID: WP_196491178.1
Location: 88630..88872 (243 bp)
Type: Others
Protein ID: WP_012535785.1
Location: 88956..89129 (174 bp)
Type: Others
Protein ID: WP_009562770.1
Location: 89240..89668 (429 bp)
Type: Others
Protein ID: WP_009562768.1
Location: 89671..90102 (432 bp)
Type: Others
Protein ID: WP_009562767.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFE_RS0039581463..82503+1041WP_012535779.1glycosyltransferase family 4 protein-
AFE_RS0040082571..83497+927WP_012535780.1glycosyltransferase family 2 protein-
AFE_RS0040583502..83858+357Protein_81glycosyltransferase-
AFE_RS0042084598..84819+222WP_009566302.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AFE_RS0042584819..85232+414WP_009566301.1type II toxin-antitoxin system VapC family toxin-
AFE_RS0043085229..85519+291WP_009566300.1hypothetical protein-
AFE_RS0043585685..85960+276WP_012535782.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AFE_RS0044085976..86293+318WP_009566298.1HigA family addiction module antidote proteinAntitoxin
AFE_RS0044586308..86487+180WP_009566297.1HNH endonuclease-
AFE_RS0045086907..88070+1164WP_009566294.1Fic family protein-
AFE_RS1656088367..88633-267WP_196491178.1hypothetical protein-
AFE_RS0046088630..88872-243WP_012535785.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AFE_RS0046588956..89129-174WP_009562770.1PCP reductase family protein-
AFE_RS0047089240..89668-429WP_009562768.1hypothetical protein-
AFE_RS0047589671..90102-432WP_009562767.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10433.84 Da        Isoelectric Point: 7.9070

>T23446 WP_012535782.1 NC_011761:85685-85960 [Acidithiobacillus ferrooxidans ATCC 23270]
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAATSPEELNVPGFDFHALEGKPKRYTVHVNGPYCITFEWREG
DAWRIDLENYH

Download         Length: 276 bp

>T23446 NC_011761:85685-85960 [Acidithiobacillus ferrooxidans ATCC 23270]
TTGATACGAAGTTTTGTGCATAAGGGCCTCAAGCAGGTTTTCGAAACAGGTCAATCGGCGAAAGTCGGTGCGGATTTGGT
AACCCGCTGCAAGCGCAGGCTCGATGCCATAAACGCTGCGACATCCCCGGAGGAGTTGAACGTGCCGGGTTTCGACTTCC
ATGCTTTGGAGGGGAAACCGAAGCGGTACACGGTTCATGTGAATGGACCCTATTGCATCACCTTCGAGTGGCGTGAAGGA
GATGCCTGGCGCATTGATCTGGAGAATTACCATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11756.54 Da        Isoelectric Point: 5.6631

>AT23446 WP_009566298.1 NC_011761:85976-86293 [Acidithiobacillus ferrooxidans ATCC 23270]
MDEMTVEQVDRIPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTVAERRLAEELAAIHKPEQAA

Download         Length: 318 bp

>AT23446 NC_011761:85976-86293 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGACGAAATGACCGTTGAGCAAGTGGATCGGATACCGACGCATCCTGGCGAGATATTGCGGGAAGAGGTACTGCCCGC
ACTGGATATCTCTGTAGCAGAGTTTGCCCGTGGCCTGCGGGTCTCGCGCCAGACCGTTCACGGCATCCTGTCTGAGCGCA
AGGGCATCACCCCGGAGATGGCCTTGCGTATCGGCAAATATCTGGGTAACGGGCCGGGGATATGGCTACGCATGCAGCAG
GCTTACGATTTGACCGTTGCAGAACGTCGGTTGGCCGAAGAACTGGCGGCCATTCACAAGCCCGAGCAGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2W1K1W3

Antitoxin

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Source
ID
Structure
No matching records found

References