Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 67314..67578 | Replicon | plasmid pKKo009_2 |
| Accession | NZ_CP091675 | ||
| Organism | Escherichia coli strain KKo009 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | L6L68_RS25065 | Protein ID | WP_001387489.1 |
| Coordinates | 67426..67578 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 67314..67374 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L68_RS25050 (63416) | 63416..64486 | - | 1071 | WP_012783932.1 | IncI1-type conjugal transfer protein TrbB | - |
| L6L68_RS25055 (64505) | 64505..65713 | - | 1209 | WP_001703845.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (65893) | 65893..65950 | - | 58 | NuclAT_1 | - | - |
| - (65893) | 65893..65950 | - | 58 | NuclAT_1 | - | - |
| - (65893) | 65893..65950 | - | 58 | NuclAT_1 | - | - |
| - (65893) | 65893..65950 | - | 58 | NuclAT_1 | - | - |
| L6L68_RS25060 (66020) | 66020..66799 | - | 780 | WP_275450201.1 | protein FinQ | - |
| - (67314) | 67314..67374 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (67314) | 67314..67374 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (67314) | 67314..67374 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (67314) | 67314..67374 | - | 61 | NuclAT_0 | - | Antitoxin |
| L6L68_RS25065 (67426) | 67426..67578 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| L6L68_RS25070 (67650) | 67650..67901 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| L6L68_RS25345 (68402) | 68402..68497 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| L6L68_RS25080 (68562) | 68562..68738 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| L6L68_RS25085 (69130) | 69130..69339 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| L6L68_RS25090 (69411) | 69411..70073 | - | 663 | WP_012783935.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| L6L68_RS25095 (70144) | 70144..72312 | - | 2169 | WP_015508354.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-55 | - | 1..89404 | 89404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T234454 WP_001387489.1 NZ_CP091675:67426-67578 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T234454 NZ_LR130544:281456-281731 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAGACCATGA
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAGACCATGA
Antitoxin
Download Length: 61 bp
>AT234454 NZ_CP091675:c67374-67314 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
