Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4397368..4397590 Replicon chromosome
Accession NZ_CP091673
Organism Escherichia coli strain KKo009

Toxin (Protein)


Gene name ldrD Uniprot ID A0A829L523
Locus tag L6L68_RS22385 Protein ID WP_000170738.1
Coordinates 4397368..4397475 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4397524..4397590 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L68_RS22355 4392397..4393968 + 1572 WP_001204944.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
L6L68_RS22360 4393965..4394156 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
L6L68_RS22365 4394153..4395832 + 1680 WP_001562264.1 cellulose biosynthesis protein BcsG -
L6L68_RS22370 4395919..4396026 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
L6L68_RS22375 4396402..4396509 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
L6L68_RS22380 4396885..4396992 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
L6L68_RS22385 4397368..4397475 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4397524..4397590 + 67 - - Antitoxin
L6L68_RS22390 4397951..4399222 + 1272 WP_001318103.1 aromatic amino acid transport family protein -
L6L68_RS22395 4399252..4400256 - 1005 WP_000107036.1 dipeptide ABC transporter ATP-binding subunit DppF -
L6L68_RS22400 4400253..4401236 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
L6L68_RS22405 4401247..4402149 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3864.67 Da        Isoelectric Point: 9.0157

>T234450 WP_000170738.1 NZ_CP091673:c4397475-4397368 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Download         Length: 108 bp

>T234450 NZ_LR130543:4073983-4074201 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 67 bp

>AT234450 NZ_CP091673:4397524-4397590 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L523

Antitoxin

Download structure file

References