Detailed information of TA system TA234446

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4395919..4396141
• Replicon: chromosome
• Accession: NZ_CP091673
• Organism: Escherichia coli strain KKo009

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: L6L68_RS22370
• Protein ID: WP_001295224.1
• Coordinates: 4395919..4396026 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4396083..4396141 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L68_RS22345	4391172..4391924	-	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-
L6L68_RS22350	4391936..4392124	-	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-
L6L68_RS22355	4392397..4393968	+	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
L6L68_RS22360	4393965..4394156	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
L6L68_RS22365	4394153..4395832	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
L6L68_RS22370	4395919..4396026	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4396083..4396141	+	59	-	-	Antitoxin
L6L68_RS22375	4396402..4396509	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
L6L68_RS22380	4396885..4396992	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
L6L68_RS22385	4397368..4397475	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
L6L68_RS22390	4397951..4399222	+	1272	WP_001318103.1	aromatic amino acid transport family protein	-
L6L68_RS22395	4399252..4400256	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T234446 WP_001295224.1 NZ_CP091673:c4396026-4395919 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T234446 NZ_LR130543:1747065-1747397 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTGACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGTGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT234446 NZ_CP091673:4396083-4396141 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin