Detailed information of TA system TA023440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5018359..5018771
• Replicon: chromosome
• Accession: NC_011750
• Organism: Escherichia coli IAI39

Toxin (Protein)

• Gene name: symE
• Uniprot ID: B7NVB3
• Locus tag: ECIAI39_RS24135
• Protein ID: WP_000132602.1
• Coordinates: 5018359..5018700 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5018695..5018771 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECIAI39_RS24110	5013425..5014705	-	1281	WP_012602676.1	DUF445 domain-containing protein	-
ECIAI39_RS24115	5014890..5015810	+	921	WP_000181197.1	Rpn family recombination-promoting nuclease/putative transposase	-
ECIAI39_RS24120	5016038..5016118	+	81	WP_020233658.1	hypothetical protein	-
ECIAI39_RS24765	5016216..5018312	+	2097	WP_000648247.1	DUF262 domain-containing protein	-
ECIAI39_RS24135	5018359..5018700	-	342	WP_000132602.1	endoribonuclease SymE	Toxin
-	5018695..5018771	+	77	NuclAT_42	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_42	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_42	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_42	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_43	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_43	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_43	-	Antitoxin
-	5018695..5018771	+	77	NuclAT_43	-	Antitoxin
ECIAI39_RS24140	5018921..5020681	-	1761	WP_000110093.1	restriction endonuclease subunit S	-
ECIAI39_RS24145	5020681..5022150	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12264.10 Da
• Isoelectric Point: 7.8219

>T23440 WP_000132602.1 NC_011750:c5018700-5018359 [Escherichia coli IAI39]
MTDTHSIAQPFEAEVSPANNRQLTVSYAGRYPDYSRIPAITLKGQWLEVAGFATGTAVDVKVMEGCIVLTAQPPAAEEGE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T23440 NC_011750:c5018700-5018359 [Escherichia coli IAI39]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGGGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGTCGCCGGTTTTGCTA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCGCCGAAGAGGGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAAAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT23440 NC_011750:5018695-5018771 [Escherichia coli IAI39]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A6C9JIC8

Antitoxin