Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3672366..3673059 Replicon chromosome
Accession NC_011750
Organism Escherichia coli IAI39

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag ECIAI39_RS17680 Protein ID WP_000415585.1
Coordinates 3672763..3673059 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ECIAI39_RS17675 Protein ID WP_000650107.1
Coordinates 3672366..3672761 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECIAI39_RS17665 3668230..3670488 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
ECIAI39_RS17670 3670626..3672233 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ECIAI39_RS17675 3672366..3672761 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ECIAI39_RS17680 3672763..3673059 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
ECIAI39_RS17685 3673264..3673746 - 483 WP_000183514.1 GyrI-like domain-containing protein -
ECIAI39_RS17690 3673799..3674191 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ECIAI39_RS17695 3674343..3675002 + 660 WP_001221493.1 two-component system response regulator QseB -
ECIAI39_RS17700 3674999..3676348 + 1350 WP_000673357.1 two-component system sensor histidine kinase QseC -
ECIAI39_RS17705 3676394..3676726 - 333 WP_000914692.1 DUF2645 family protein -
ECIAI39_RS17710 3676733..3677925 - 1193 Protein_3460 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T23434 WP_000415585.1 NC_011750:c3673059-3672763 [Escherichia coli IAI39]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T23434 NC_011750:c3673059-3672763 [Escherichia coli IAI39]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT23434 WP_000650107.1 NC_011750:c3672761-3672366 [Escherichia coli IAI39]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT23434 NC_011750:c3672761-3672366 [Escherichia coli IAI39]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References