Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 716876..717569 Replicon chromosome
Accession NZ_CP091662
Organism Escherichia coli strain KFu023

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag L6L71_RS03510 Protein ID WP_000415585.1
Coordinates 716876..717172 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L71_RS03515 Protein ID WP_000650107.1
Coordinates 717174..717569 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L71_RS03475 (712010) 712010..712489 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
L6L71_RS03480 (712492) 712492..713202 + 711 WP_000834030.1 hypothetical protein -
L6L71_RS03485 (713209) 713209..713541 + 333 WP_000914690.1 DUF2645 family protein -
L6L71_RS03490 (713587) 713587..714936 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
L6L71_RS03495 (714933) 714933..715592 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
L6L71_RS03500 (715744) 715744..716136 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L71_RS03505 (716189) 716189..716671 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L71_RS03510 (716876) 716876..717172 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L71_RS03515 (717174) 717174..717569 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L71_RS03520 (717702) 717702..719309 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
L6L71_RS03525 (719447) 719447..721705 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T234333 WP_000415585.1 NZ_CP091662:716876-717172 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234333 NZ_LR130527:c3256349-3256068 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAAGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234333 WP_000650107.1 NZ_CP091662:717174-717569 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234333 NZ_LR130527:c3256573-3256346 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References