Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1266999..1267692 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L61_RS07000 Protein ID WP_000415584.1
Coordinates 1267396..1267692 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L61_RS06995 Protein ID WP_000650107.1
Coordinates 1266999..1267394 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS06985 (1262863) 1262863..1265121 - 2259 WP_096037756.1 DNA topoisomerase IV subunit A -
L6L61_RS06990 (1265259) 1265259..1266866 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L61_RS06995 (1266999) 1266999..1267394 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L61_RS07000 (1267396) 1267396..1267692 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L61_RS07005 (1267897) 1267897..1268379 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L61_RS07010 (1268432) 1268432..1268824 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L6L61_RS07015 (1268976) 1268976..1269635 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L61_RS07020 (1269632) 1269632..1270981 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6L61_RS07025 (1271027) 1271027..1271360 - 334 Protein_1208 DUF2645 family protein -
L6L61_RS07030 (1271679) 1271679..1272260 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L61_RS07035 (1272291) 1272291..1272605 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234305 WP_000415584.1 NZ_CP091659:c1267692-1267396 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234305 NZ_LR130513:c2478857-2478591 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234305 WP_000650107.1 NZ_CP091659:c1267394-1266999 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234305 NZ_LR130513:c2479108-2478857 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References