Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 18707..18971 | Replicon | plasmid pKMi025_2 |
| Accession | NZ_CP091653 | ||
| Organism | Escherichia coli strain KMi025 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | L6L63_RS23430 | Protein ID | WP_001303307.1 |
| Coordinates | 18819..18971 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 18707..18769 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L63_RS23415 (13946) | 13946..16237 | - | 2292 | WP_240724999.1 | F-type conjugative transfer protein TrbC | - |
| L6L63_RS23420 (16230) | 16230..17300 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| L6L63_RS23425 (17319) | 17319..18527 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (18707) | 18707..18769 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (18707) | 18707..18769 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (18707) | 18707..18769 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (18707) | 18707..18769 | - | 63 | NuclAT_0 | - | Antitoxin |
| L6L63_RS23430 (18819) | 18819..18971 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| L6L63_RS23435 (19043) | 19043..19294 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| L6L63_RS23440 (19773) | 19773..20528 | - | 756 | WP_001282653.1 | IS21-like element ISSso4 family helper ATPase IstB | - |
| L6L63_RS23445 (20545) | 20545..22080 | - | 1536 | WP_045147483.1 | IS21 family transposase | - |
| - (22325) | 22325..22376 | - | 52 | NuclAT_1 | - | - |
| - (22325) | 22325..22376 | - | 52 | NuclAT_1 | - | - |
| - (22325) | 22325..22376 | - | 52 | NuclAT_1 | - | - |
| - (22325) | 22325..22376 | - | 52 | NuclAT_1 | - | - |
| L6L63_RS23450 (22862) | 22862..23038 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| L6L63_RS23455 (23430) | 23430..23639 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-8 | - | 1..113312 | 113312 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T234276 WP_001303307.1 NZ_CP091653:18819-18971 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T234276 NZ_LR130509:372362-372661 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTCGTTGAAGATAAATTTGTCAAAAATAAATTAGAAACAAAACAAGAACATATCAGTTACTCAGCAGGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAGATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG
ATGAATTGGGAAATTAAAGATTTAATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTCGTTGAAGATAAATTTGTCAAAAATAAATTAGAAACAAAACAAGAACATATCAGTTACTCAGCAGGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAGATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG
Antitoxin
Download Length: 63 bp
>AT234276 NZ_CP091653:c18769-18707 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
