Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4452620..4453374 Replicon chromosome
Accession NZ_CP091640
Organism Salmonella enterica strain 965

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5503_RS21245 Protein ID WP_133323219.1
Coordinates 4452620..4452931 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5503_RS21250 Protein ID WP_001259009.1
Coordinates 4452928..4453374 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5503_RS21215 (4448278) 4448278..4449180 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5503_RS21220 (4449177) 4449177..4449812 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5503_RS21225 (4449809) 4449809..4450738 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5503_RS21230 (4450785) 4450785..4451075 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5503_RS21235 (4451076) 4451076..4451387 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5503_RS21240 (4451605) 4451605..4452534 + 930 WP_001127694.1 alpha/beta hydrolase -
L5503_RS21245 (4452620) 4452620..4452931 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5503_RS21250 (4452928) 4452928..4453374 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5503_RS21255 (4453389) 4453389..4454330 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5503_RS21260 (4454375) 4454375..4454812 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5503_RS21265 (4454809) 4454809..4455681 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5503_RS21270 (4455675) 4455675..4456274 - 600 WP_000965698.1 glucose-1-phosphatase -
L5503_RS21275 (4456465) 4456465..4457268 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5503_RS21280 (4457302) 4457302..4458198 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T234192 WP_133323219.1 NZ_CP091640:4452620-4452931 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T234192 NZ_LR027870:c2081511-2081335 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT234192 WP_001259009.1 NZ_CP091640:4452928-4453374 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT234192 NZ_LR027870:2081212-2081267 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References