Detailed information of TA system TA234191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4450785..4451387
• Replicon: chromosome
• Accession: NZ_CP091640
• Organism: Salmonella enterica strain 965

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5503_RS21235
• Protein ID: WP_001159630.1
• Coordinates: 4451076..4451387 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5503_RS21230
• Protein ID: WP_000362050.1
• Coordinates: 4450785..4451075 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5503_RS21215 (4448278)	4448278..4449180	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5503_RS21220 (4449177)	4449177..4449812	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5503_RS21225 (4449809)	4449809..4450738	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5503_RS21230 (4450785)	4450785..4451075	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5503_RS21235 (4451076)	4451076..4451387	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5503_RS21240 (4451605)	4451605..4452534	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5503_RS21245 (4452620)	4452620..4452931	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5503_RS21250 (4452928)	4452928..4453374	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5503_RS21255 (4453389)	4453389..4454330	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5503_RS21260 (4454375)	4454375..4454812	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5503_RS21265 (4454809)	4454809..4455681	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5503_RS21270 (4455675)	4455675..4456274	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234191 WP_001159630.1 NZ_CP091640:c4451387-4451076 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234191 NZ_LR027870:c1977855-1977703 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234191 WP_000362050.1 NZ_CP091640:c4451075-4450785 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234191 NZ_LR027870:c1978479-1977880 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64