Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4489536..4490290 Replicon chromosome
Accession NZ_CP091634
Organism Salmonella enterica strain 1116

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5505_RS21490 Protein ID WP_133323219.1
Coordinates 4489536..4489847 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5505_RS21495 Protein ID WP_001259009.1
Coordinates 4489844..4490290 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5505_RS21460 (4485194) 4485194..4486096 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5505_RS21465 (4486093) 4486093..4486728 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5505_RS21470 (4486725) 4486725..4487654 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5505_RS21475 (4487701) 4487701..4487991 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5505_RS21480 (4487992) 4487992..4488303 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5505_RS21485 (4488521) 4488521..4489450 + 930 WP_001127694.1 alpha/beta hydrolase -
L5505_RS21490 (4489536) 4489536..4489847 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5505_RS21495 (4489844) 4489844..4490290 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5505_RS21500 (4490305) 4490305..4491246 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5505_RS21505 (4491291) 4491291..4491728 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5505_RS21510 (4491725) 4491725..4492597 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5505_RS21515 (4492591) 4492591..4493190 - 600 WP_000965698.1 glucose-1-phosphatase -
L5505_RS21520 (4493381) 4493381..4494184 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5505_RS21525 (4494218) 4494218..4495114 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T234152 WP_133323219.1 NZ_CP091634:4489536-4489847 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T234152 NZ_LR027516:2938343-2938783 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT234152 WP_001259009.1 NZ_CP091634:4489844-4490290 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT234152 NZ_LR027516:2938069-2938356 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References