Detailed information of TA system TA234151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4487701..4488303
• Replicon: chromosome
• Accession: NZ_CP091634
• Organism: Salmonella enterica strain 1116

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5505_RS21480
• Protein ID: WP_001159630.1
• Coordinates: 4487992..4488303 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5505_RS21475
• Protein ID: WP_000362050.1
• Coordinates: 4487701..4487991 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5505_RS21460 (4485194)	4485194..4486096	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5505_RS21465 (4486093)	4486093..4486728	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5505_RS21470 (4486725)	4486725..4487654	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5505_RS21475 (4487701)	4487701..4487991	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5505_RS21480 (4487992)	4487992..4488303	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5505_RS21485 (4488521)	4488521..4489450	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5505_RS21490 (4489536)	4489536..4489847	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5505_RS21495 (4489844)	4489844..4490290	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5505_RS21500 (4490305)	4490305..4491246	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5505_RS21505 (4491291)	4491291..4491728	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5505_RS21510 (4491725)	4491725..4492597	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5505_RS21515 (4492591)	4492591..4493190	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234151 WP_001159630.1 NZ_CP091634:c4488303-4487992 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234151 NZ_LR027516:c2878129-2877734 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234151 WP_000362050.1 NZ_CP091634:c4487991-4487701 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234151 NZ_LR027516:c2878371-2878126 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64