Detailed information of TA system TA234133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4494820..4495574
• Replicon: chromosome
• Accession: NZ_CP091630
• Organism: Salmonella enterica strain 1147

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L5506_RS21515
• Protein ID: WP_133323219.1
• Coordinates: 4494820..4495131 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5506_RS21520
• Protein ID: WP_001259009.1
• Coordinates: 4495128..4495574 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5506_RS21485 (4490478)	4490478..4491380	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5506_RS21490 (4491377)	4491377..4492012	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5506_RS21495 (4492009)	4492009..4492938	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5506_RS21500 (4492985)	4492985..4493275	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
L5506_RS21505 (4493276)	4493276..4493587	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
L5506_RS21510 (4493805)	4493805..4494734	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5506_RS21515 (4494820)	4494820..4495131	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
L5506_RS21520 (4495128)	4495128..4495574	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
L5506_RS21525 (4495589)	4495589..4496530	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5506_RS21530 (4496575)	4496575..4497012	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5506_RS21535 (4497009)	4497009..4497881	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5506_RS21540 (4497875)	4497875..4498474	-	600	WP_000965698.1	glucose-1-phosphatase	-
L5506_RS21545 (4498665)	4498665..4499468	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
L5506_RS21550 (4499502)	4499502..4500398	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T234133 WP_133323219.1 NZ_CP091630:4494820-4495131 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T234133 NZ_LR027516:1701187-1701504 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT234133 WP_001259009.1 NZ_CP091630:4495128-4495574 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT234133 NZ_LR027516:1700888-1701190 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA