Detailed information of TA system TA234132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4492985..4493587
• Replicon: chromosome
• Accession: NZ_CP091630
• Organism: Salmonella enterica strain 1147

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5506_RS21505
• Protein ID: WP_001159630.1
• Coordinates: 4493276..4493587 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5506_RS21500
• Protein ID: WP_000362050.1
• Coordinates: 4492985..4493275 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5506_RS21485 (4490478)	4490478..4491380	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5506_RS21490 (4491377)	4491377..4492012	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5506_RS21495 (4492009)	4492009..4492938	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5506_RS21500 (4492985)	4492985..4493275	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5506_RS21505 (4493276)	4493276..4493587	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5506_RS21510 (4493805)	4493805..4494734	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5506_RS21515 (4494820)	4494820..4495131	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5506_RS21520 (4495128)	4495128..4495574	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5506_RS21525 (4495589)	4495589..4496530	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5506_RS21530 (4496575)	4496575..4497012	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5506_RS21535 (4497009)	4497009..4497881	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5506_RS21540 (4497875)	4497875..4498474	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234132 WP_001159630.1 NZ_CP091630:c4493587-4493276 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234132 NZ_LR027516:c1588887-1588486 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234132 WP_000362050.1 NZ_CP091630:c4493275-4492985 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234132 NZ_LR027516:c1589141-1588884 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64