Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4458705..4459459 Replicon chromosome
Accession NZ_CP091626
Organism Salmonella enterica strain 1165

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5507_RS21265 Protein ID WP_133323219.1
Coordinates 4458705..4459016 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5507_RS21270 Protein ID WP_001259009.1
Coordinates 4459013..4459459 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5507_RS21235 (4454363) 4454363..4455265 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5507_RS21240 (4455262) 4455262..4455897 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5507_RS21245 (4455894) 4455894..4456823 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5507_RS21250 (4456870) 4456870..4457160 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5507_RS21255 (4457161) 4457161..4457472 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5507_RS21260 (4457690) 4457690..4458619 + 930 WP_001127694.1 alpha/beta hydrolase -
L5507_RS21265 (4458705) 4458705..4459016 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5507_RS21270 (4459013) 4459013..4459459 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5507_RS21275 (4459474) 4459474..4460415 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5507_RS21280 (4460460) 4460460..4460897 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5507_RS21285 (4460894) 4460894..4461766 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5507_RS21290 (4461760) 4461760..4462359 - 600 WP_000965698.1 glucose-1-phosphatase -
L5507_RS21295 (4462550) 4462550..4463353 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5507_RS21300 (4463387) 4463387..4464283 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T234114 WP_133323219.1 NZ_CP091626:4458705-4459016 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T234114 NZ_LR027516:c707412-707020 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT234114 WP_001259009.1 NZ_CP091626:4459013-4459459 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT234114 NZ_LR027516:c707666-707409 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References