Detailed information of TA system TA234113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4456870..4457472
• Replicon: chromosome
• Accession: NZ_CP091626
• Organism: Salmonella enterica strain 1165

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5507_RS21255
• Protein ID: WP_001159630.1
• Coordinates: 4457161..4457472 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5507_RS21250
• Protein ID: WP_000362050.1
• Coordinates: 4456870..4457160 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5507_RS21235 (4454363)	4454363..4455265	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5507_RS21240 (4455262)	4455262..4455897	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5507_RS21245 (4455894)	4455894..4456823	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5507_RS21250 (4456870)	4456870..4457160	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5507_RS21255 (4457161)	4457161..4457472	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5507_RS21260 (4457690)	4457690..4458619	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5507_RS21265 (4458705)	4458705..4459016	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5507_RS21270 (4459013)	4459013..4459459	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5507_RS21275 (4459474)	4459474..4460415	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5507_RS21280 (4460460)	4460460..4460897	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5507_RS21285 (4460894)	4460894..4461766	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5507_RS21290 (4461760)	4461760..4462359	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234113 WP_001159630.1 NZ_CP091626:c4457472-4457161 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234113 NZ_LR027516:690103-690510 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234113 WP_000362050.1 NZ_CP091626:c4457160-4456870 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234113 NZ_LR027516:689891-690106 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64