Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4497433..4498187 Replicon chromosome
Accession NZ_CP091624
Organism Salmonella enterica strain 1382

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L5508_RS21515 Protein ID WP_133323219.1
Coordinates 4497433..4497744 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L5508_RS21520 Protein ID WP_001259009.1
Coordinates 4497741..4498187 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5508_RS21485 (4493091) 4493091..4493993 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L5508_RS21490 (4493990) 4493990..4494625 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
L5508_RS21495 (4494622) 4494622..4495551 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L5508_RS21500 (4495598) 4495598..4495888 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L5508_RS21505 (4495889) 4495889..4496200 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L5508_RS21510 (4496418) 4496418..4497347 + 930 WP_001127694.1 alpha/beta hydrolase -
L5508_RS21515 (4497433) 4497433..4497744 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
L5508_RS21520 (4497741) 4497741..4498187 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L5508_RS21525 (4498202) 4498202..4499143 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L5508_RS21530 (4499188) 4499188..4499625 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
L5508_RS21535 (4499622) 4499622..4500494 - 873 WP_000921423.1 virulence factor BrkB family protein -
L5508_RS21540 (4500488) 4500488..4501087 - 600 WP_000965698.1 glucose-1-phosphatase -
L5508_RS21545 (4501278) 4501278..4502081 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
L5508_RS21550 (4502115) 4502115..4503011 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T234095 WP_133323219.1 NZ_CP091624:4497433-4497744 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T234095 NZ_LR025101:c4064173-4063766 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT234095 WP_001259009.1 NZ_CP091624:4497741-4498187 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT234095 NZ_LR025101:c4064420-4064154 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References